Project Grant R01NS150352
- This $124,632 project grant from the National Institute of Neurological Disorders and Stroke will support the development of a testable biologically constrained model for path integration in fruit flies. Funded under the Extramural Research Programs in the Neurosciences and Neurological Disorders program, the awardee will use agent-based modeling, pattern recognition algorithms on flies' search trajectories, and genetic manipulation to test the roles of specific cells in the central complex of...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Princeton University $132,813 on April 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing 93.853) to characterize multimodal processing with whole-brain approaches in Drosophila. The research employs whole-brain functional imaging in behaving animals, connectome-constrained computational models, and a range of modern...
- The National Institute of Neurological Disorders and Stroke awarded The University of Chicago $603,293 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize how proprioceptive sensory information is processed through projection and local neural pathways in Drosophila larvae. The research uses two technical innovations—CRASH2P microscopy for volumetric imaging of neural dynamics in intact, freely moving...
- The National Eye Institute awarded the University of California, Los Angeles $114,789 on July 1, 2026, under the Vision Research program (CFDA 93.867) to investigate feature detection mechanisms driving saccades in Drosophila. The project runs through June 30, 2028, with performance at Los Angeles, California. The research uses fruit fly connectome data and genetic tools to map how elementary feature detectors in the visual system convert visual information into saccadic eye movements. Three...
- The National Institute of Neurological Disorders and Stroke awarded Max Planck Florida Corp (doing business as Max Planck Florida Institute For Neuroscience) $518,582 in project grant funding on May 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of sensory-motor transformations in neural circuits controlling object-directed walking in Drosophila melanogaster. The research examines how visual...
- The National Institute of Neurological Disorders and Stroke awarded Texas A&M University $500,307 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cross-neuronal structural plasticity in Drosophila motor circuits. The research addresses how different neuron and synapse types undergo structural rewiring in response to neural injury, with focus on how premotor neurons, motor neurons, and muscles in...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $639,875 on August 10, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS151292). The recipient will characterize the molecular steps that allow post-mitotic neurons to correctly integrate into neural circuits, focusing on motor neurons that target adult leg muscles in...
- The National Institute of Neurological Disorders and Stroke awarded the Research Foundation of the City University of New York $1,120,500 on September 30, 2025, under the Vision Research program (CFDA 93.867) to investigate the regulation of neuron cell number and dendrite arbor size in the Drosophila visual system. The research employs the fruit fly visual system as a model to understand how sensory neurons scale their dendrites to evenly sample their environment. The work focuses on distal...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UCLA a Project Grant totaling $551,250 on June 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research focuses on understanding the molecular basis of synaptic specificity in the Drosophila melanogaster visual system. The project will investigate how neurons form precise synaptic connections through cell...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
The National Institute of Neurological Disorders and Stroke awarded California Institute of Technology $408,947 on September 1, 2026, under Assistance Listing 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to investigate the neural mechanisms underlying temporal integration in the fruit fly Drosophila, with research performed in Pasadena, California through August 31, 2031. The project uses the haltere-motor sensory system in fruit flies—which detects angular velocity analogously to vertebrate gaze control circuits—as a model to elucidate how the brain accumulates sensory information over time. This temporal integration process is central to behaviors including the vestibulo-ocular reflex in humans and maintenance of posture and coordinated movement; disruption causes gaze instability, nystagmus, and movement disorders. The work integrates connectomics, optogenetics, whole-cell electrophysiology, and computational modeling across three aims: identifying candidate neurons performing temporal integration and establishing genetic driver lines; determining molecular, cellular, and network mechanisms enabling sensory signal integration; and synthesizing anatomical and physiological data into computational models of the integration circuit. The research leverages the fruit fly's fully mapped connectome, genetic tractability, and amenability to precise neural recording and manipulation in behaving animals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.9k | 8/31/26 |