Project Grant R21NS152034
- The National Institute of Neurological Disorders and Stroke awarded Emory University $234,750 on May 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate NMDA receptor regulation of rapid synaptic scaling and spinal excitability in fragile X syndrome. The research will identify mechanisms controlling maturation of network excitability during neonatal development, with focus on how NMDA receptor blockade triggers...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $625,859 on January 27, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate objective, quantitative measures of infant motor function as predictive biomarkers for autism spectrum disorder. The project uses wearable sensor technology and advanced computational techniques to measure motor development...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $534,557 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of Renshaw cells and recurrent inhibition during motor behaviors. The research examines how Renshaw cells—inhibitory interneurons within the spinal cord's output-regulating microcircuit—contribute to coordinated limb movements and motor control in...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $575,485 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of the BCL11A gene in neuron function and neurological disease. The award funds research examining how BCL11A, a zinc-finger transcription factor, contributes to intellectual disability, autism spectrum disorder, epilepsy, schizophrenia, and...
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $490,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of growth differentiation factor 11 (GDF11) in neurodevelopmental disorders. The research examines GDF11 as a molecular hub involved in abnormal brain function across multiple genetically distinct neurodevelopmental disorders. The first...
- The National Institute of Mental Health awarded The Washington University $811,412 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to establish specificity and scalability of motor imitation assessments as a biomarker for autism spectrum disorder. The research combines wearable high-density diffuse optical tomography functional neuroimaging with a computerized assessment of motor imitation to evaluate whether imitation deficits distinguish ASD from overlapping...
- The National Institute of Neurological Disorders and Stroke awarded Miami University $539,920 on September 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how TSC1 loss disrupts Purkinje neuron axon initial segment organization and cerebellar function in autism spectrum disorder. The research examines the cellular mechanisms by which TSC1 deletion in Purkinje neurons alters axon initial segment function and...
- The National Institute of Neurological Disorders and Stroke awarded the University of Southern California $181,891 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the RNA-regulatory activities of the RNA exosome during human motor neuron differentiation. The research examines how the RNA exosome, a post-transcriptional ribonuclease complex, regulates gene expression during stem cell differentiation...
- Federal Project Grant Award Summary Emory University received a $430,375 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded July 1, 2025, with completion expected June 30, 2027. This award funds research investigating membrane trafficking impairments in Fragile X Syndrome (FXS), the most common form of inherited intellectual disability and...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $234,750 on January 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neuromodulation of somato-sympathetic postganglionic activity after spinal cord injury. The research develops animal models incorporating clinically analogous epidural spinal cord stimulation to understand how neuromodulation can restore autonomic function...
The National Institute of Neurological Disorders and Stroke awarded Emory University $430,375 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spinal motor circuit dysfunction in autism spectrum disorder. The project examines the neural mechanisms underlying early motor impairments in ASD using two complementary mouse models: prenatal valproic acid exposure (representing environmental and epigenetic risk) and the 16p11.2 deletion model (representing a high-confidence genetic cause). Aim 1 characterizes early motor development and assesses motoneuron number, spatial organization, and expression of three 16p11.2 genes—MAPK3, TAOK2, and KCTD13—at single-cell resolution using multiplex RNAscope and immunofluorescence. Aim 2 tests the recruitment and synaptic integrity of lumbar motoneurons by reticulospinal and vestibulospinal pathways using ex vivo calcium imaging and cre-dependent synaptophysin-GFP labeling of descending terminals. The work integrates behavioral, anatomical, molecular, and physiological analyses to link specific cellular and circuit alterations to measurable early motor outcomes, with the goal of identifying biomarkers for early ASD detection and intervention. Performance takes place at Emory University in Atlanta, Georgia. The award period runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.4k | 8/31/26 |