Project Grant R56NS147432
- The National Institute of Neurological Disorders and Stroke awarded Emory University $428,218 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop subcellularly resolved spatial genomics approaches for studying axon regeneration. The research maps the nerve regenerative landscape by building a three-dimensional spatial single-cell transcriptomics atlas of dorsal root ganglia in mice, training a...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $234,750 on January 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neuromodulation of somato-sympathetic postganglionic activity after spinal cord injury. The research develops animal models incorporating clinically analogous epidural spinal cord stimulation to understand how neuromodulation can restore autonomic function...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $534,666 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how the primary motor cortex directly influences muscle activity during naturalistic motor behaviors. The research develops and applies a novel technical approach combining rapid silencing of motor cortical output with electromyographic muscle activity...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $577,611 on January 23, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how cell-specific neural activity contributes to resting-state functional magnetic resonance imaging (rs-fMRI) patterns in the brain. The research develops and deploys simultaneous wide-field optical imaging (WOI) and rs-fMRI methodology to detect...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $234,750 on May 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate NMDA receptor regulation of rapid synaptic scaling and spinal excitability in fragile X syndrome. The research will identify mechanisms controlling maturation of network excitability during neonatal development, with focus on how NMDA receptor blockade triggers...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $460,839 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to cultivate rigor in movement neuroscience research by aligning professional incentives with rigorous study design practices. Emory will establish community-focused programs to address the reproducibility crisis in movement neuroscience by creating incentives that...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $430,375 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spinal motor circuit dysfunction in autism spectrum disorder. The project examines the neural mechanisms underlying early motor impairments in ASD using two complementary mouse models: prenatal valproic acid exposure (representing environmental and...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $639,875 on August 10, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS151292). The recipient will characterize the molecular steps that allow post-mitotic neurons to correctly integrate into neural circuits, focusing on motor neurons that target adult leg muscles in...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $547,750 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate human-specific mechanisms governing miR-124 regulation of neuronal development. The research focuses on microRNA biogenesis and function in the human brain, specifically examining how miR-124—the most abundant microRNA in brain tissue—controls spatiotemporal...
The National Institute of Neurological Disorders and Stroke awarded Emory University $534,557 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of Renshaw cells and recurrent inhibition during motor behaviors. The research examines how Renshaw cells—inhibitory interneurons within the spinal cord's output-regulating microcircuit—contribute to coordinated limb movements and motor control in freely behaving animals. The project addresses a gap between decades of knowledge about synaptic connectivity and connectivity within this microcircuit and the lack of validated hypotheses describing how these interneurons function during actual motor actions. Renshaw cells mediate recurrent inhibition of motoneurons and modulate IA inhibitory interneurons, yet their influence on motor execution remains debated. The research will leverage recent methodological developments to interfere with Renshaw cell function while recording motoneuron activity and movement in unrestrained animals, moving from correlative hypotheses to causal demonstrations of their impact on motor output and movement. Understanding this microcircuit has direct relevance to motor dysfunctions including spasticity, posture and balance deficits in older age, and motor deficits following stroke, spinal cord injury, and amyotrophic lateral sclerosis. Performance occurs in Atlanta, Georgia. The award runs from September 1, 2026, through August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $534.6k | 8/13/26 |