Project Grant R21NS151664
- The National Institute of Neurological Disorders and Stroke awarded Brown University $473,561 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of endoplasmic reticulum membrane contact sites in synapse formation and plasticity. The award funds research on PDZD8, an endoplasmic-reticulum-resident tethering protein linked to intellectual disability that regulates activity-dependent...
- The National Institute of Neurological Disorders and Stroke awarded Brown University $116,510 on June 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate chromatin-based mechanisms linking transcriptional dysregulation to genome instability in neurodevelopmental disorders. The research examines how dysregulated histone H3 lysine 4 (H3K4) methylation compromises genome integrity in human neurons, potentially...
- The National Institute of Neurological Disorders and Stroke awarded Brown University $408,585 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, assistance type: Project Grant R21NS142903). The award funds research identifying conserved cellular mechanisms involved in alternating hemiplegia of childhood (AHC), a disease caused by dominant mutations in ATP1A3, which encodes a sodium/potassium-ATPase pump critical to...
- The National Institute of Neurological Disorders and Stroke awarded Brigham Young University $550,159 on June 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of MAB-5, a Hox transcription factor, in establishing and maintaining neuronal identity and connectivity. The research uses C. elegans Q neuroblasts as a model system to elucidate mechanisms of neuronal cell fate generation and maintenance. The...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $462,052 under Project Grant R21NS150995 on August 21, 2026, to develop an automated, scalable framework for linking neuronal activity with genetic identity across the peripheral and central nervous systems. The project addresses a gap in current neuroscience methodology by integrating in vivo imaging of neuronal dynamics with spatial transcriptomics to map gene expression patterns directly to neural activity...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during...
- The National Institute of Neurological Disorders and Stroke awarded New York University $638,783 on May 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how mammalian posterior group Hox transcription factors diversify their function to pattern the spinal cord during embryonic development. Research activities span two primary aims: examination of protein domains and specific Hox amino acids in HOXC9 and HOXC13...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
The National Institute of Neurological Disorders and Stroke awarded Brown University $408,585 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R21NS151664). The award funds research into gene-regulatory mechanisms controlling stepwise axon pathfinding during neural circuit assembly. The work uses mouse spinal commissular neurons to investigate how axonal contact with intermediate targets triggers changes in neuronal gene expression via dedicated transcription factors, thereby modulating responses to axon guidance cues. The project employs gene-regulatory network inference methods, gain-of-function and loss-of-function approaches, and molecular profiling to test a model in which axon-intermediate target contact alters the abundance of axonal proteins involved in directional guidance before and after midline crossing. Performance occurs in Providence, Rhode Island 02903, with period of performance through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.6k | 9/3/26 |