Project Grant R56NS146176
- The National Institute of Neurological Disorders and Stroke awarded Brown University $408,585 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R21NS151664). The award funds research into gene-regulatory mechanisms controlling stepwise axon pathfinding during neural circuit assembly. The work uses mouse spinal commissular neurons to investigate how axonal contact with intermediate targets triggers...
- The National Institute of Neurological Disorders and Stroke awarded Brown University $116,510 on June 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate chromatin-based mechanisms linking transcriptional dysregulation to genome instability in neurodevelopmental disorders. The research examines how dysregulated histone H3 lysine 4 (H3K4) methylation compromises genome integrity in human neurons, potentially...
- The National Institute of Neurological Disorders and Stroke awarded New York University $550,743 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the mechanisms of assembly of endocytic machinery at the periactive zone and its coupling to the presynaptic active zone. The research dissects how the large GTPase dynamin organizes both the active zone, where neurotransmitters are released from...
- The National Institute of Neurological Disorders and Stroke awarded Brown University $408,585 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, assistance type: Project Grant R21NS142903). The award funds research identifying conserved cellular mechanisms involved in alternating hemiplegia of childhood (AHC), a disease caused by dominant mutations in ATP1A3, which encodes a sodium/potassium-ATPase pump critical to...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $513,602 on June 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to define the role of non-clustered protocadherins in forebrain circuit assembly and complex behavioral execution. The research explores how non-clustered protocadherins, including protocadherin-17, establish reciprocal connectivity patterns between forebrain regions—the cerebral...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $595,208 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS148534). The award funds research investigating striatal synaptic plasticity mechanisms underlying cognitive dysfunction in Parkinson's disease. The project examines circuit- and synaptic-level...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital Inc. $557,883 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating pathogenic mechanisms of leucine-rich repeat kinase 2 (LRRK2) mutations linked to familial Parkinson's disease, dementia with Lewy bodies, and tauopathies. The research examines whether mitochondrial and...
The National Institute of Neurological Disorders and Stroke awarded Brown University $473,561 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of endoplasmic reticulum membrane contact sites in synapse formation and plasticity. The award funds research on PDZD8, an endoplasmic-reticulum-resident tethering protein linked to intellectual disability that regulates activity-dependent synaptogenesis. The project combines genetic studies, live and superresolution imaging, and proteomic analysis to define PDZD8's in vivo role in synapse formation, lysosome maturation, and autophagy during high neuronal demand. The work addresses fundamental questions about membrane contact sites' critical roles in the nervous system and their relationship to neurological disorders including lysosomal storage disorders, hereditary spastic paraplegia, and neurodegeneration. Performance occurs in Providence, Rhode Island. The period of performance runs from September 1, 2026, through August 31, 2027. This is a Project Grant, the standard assistance type for investigator-initiated research within the NINDS extramural portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $473.6k | 9/1/26 |