Project Grant R21NS150995
- The National Institute of Neurological Disorders and Stroke awarded Yale University $462,855 under grant R21NS147184 on September 1, 2026, to develop and characterize isogenic neuronal cell models carrying mitochondrial DNA mutations implicated in neurological diseases. The recipient will establish human immortalized neuronal cell lines and induced pluripotent stem cell–derived neurons harboring pathogenic mitochondrial DNA mutations across oxidative phosphorylation complexes I, III, IV, V,...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $513,602 on June 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to define the role of non-clustered protocadherins in forebrain circuit assembly and complex behavioral execution. The research explores how non-clustered protocadherins, including protocadherin-17, establish reciprocal connectivity patterns between forebrain regions—the cerebral...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $428,218 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop subcellularly resolved spatial genomics approaches for studying axon regeneration. The research maps the nerve regenerative landscape by building a three-dimensional spatial single-cell transcriptomics atlas of dorsal root ganglia in mice, training a...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $461,197 on March 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop plasma-based biomarkers for stratifying amyotrophic lateral sclerosis patients into distinct molecular subtypes. The project leverages a collection of matched plasma samples and autopsied motor cortices from fifty ALS patients previously categorized into three...
- The National Institute of Neurological Disorders and Stroke awarded a cooperative agreement to Yale University on April 15, 2026, totaling $1.379 million under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Yale is developing stimuli-responsive traceless engineering platform ribonucleoproteins (STEP RNPs) for brain delivery of CRISPR-based genome editing targeting the MAPT gene to reduce tau protein levels in Alzheimer's disease. The...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Yale University $272,970 under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative on September 30, 2025. The award funds research on neural circuits regulating arousal and behavioral responses to visual threats. The project employs a virtual visual cliff task in mice to study the relationship between neuromodulators (norepinephrine and acetylcholine), attention, arousal, sensory...
- The National Institute of Neurological Disorders and Stroke awarded The Scripps Research Institute $710,155 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate post-transcriptional mechanisms of cortical inhibitory interneuron development. The research focuses on identifying how microRNA-mediated regulation controls interneuron migration and specification during development. The work employs engineered...
The National Institute of Neurological Disorders and Stroke awarded Yale University $462,052 under Project Grant R21NS150995 on August 21, 2026, to develop an automated, scalable framework for linking neuronal activity with genetic identity across the peripheral and central nervous systems. The project addresses a gap in current neuroscience methodology by integrating in vivo imaging of neuronal dynamics with spatial transcriptomics to map gene expression patterns directly to neural activity at single-cell resolution. Current approaches require extensive manual annotation, rely on limited genetic markers, and depend on specialized transgenic models. The award funds development of a unified experimental-computational framework that automates alignment of functional imaging and spatial transcriptomics datasets, eliminating barriers to broad adoption across laboratories and species. Performance takes place in New Haven, Connecticut, with a period of performance through July 31, 2028. The award is made under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), which supports extramural research conducted by NINDS exploring fundamental structure and function of the brain and nervous system to reduce the burden of neurological disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $462.1k | 8/21/26 |