Project Grant R21NS149191
Award Date 9/15/26
Completion Date 8/31/28
Dollars Obligated $192K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
- The National Institute of Neurological Disorders and Stroke awarded the University of Pennsylvania $203,125 on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of a combined metabolic and microstructural imaging approach to identify neurodegeneration along the corticospinal tract in amyotrophic lateral sclerosis patients. The project proposes to fuse whole-brain spectroscopic imaging...
- The National Institute on Aging awarded the University of Pennsylvania $425,235 on February 1, 2026, under the Aging Research program (CFDA 93.866) to decode antigen-specific T cells in frontotemporal degeneration. The research investigates the role of CD8+ T cells recognizing cryptic peptides derived from TDP-43 pathology in frontotemporal dementia (FTD). Approximately 50 percent of FTD cases involve TDP-43 pathology that generates cryptic exons; emerging evidence suggests these cryptic...
- The National Institute on Aging awarded the University of Pennsylvania $6.72 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to develop short RNA therapeutics targeting TDP-43 proteinopathy across amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, and chronic traumatic encephalopathy. The recipient will identify and characterize short oligonucleotides that engage the TDP-43 protein,...
- The National Institute of Allergy and Infectious Diseases awarded Brigham and Women's Hospital Inc. $823,143 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate regulatory T cell (Treg) defects in amyotrophic lateral sclerosis. The research aims to identify why Tregs are functionally deficient in ALS patients and what causes their reduced frequency. Prior evidence shows that ALS patients exhibit lower Treg frequency and reduced Treg function...
- Federal Grant Award Summary The University of Pennsylvania received a $3.2 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 1, 2025, with completion targeted for July 31, 2029. This research initiative will identify genetic modifiers contributing to phenotypic heterogeneity in the amyotrophic lateral sclerosis (ALS) and...
- The National Institute of Neurological Disorders and Stroke awarded Thomas Jefferson University $195,000 on May 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to map and validate RNA G-quadruplex (GQ) structures at TDP-43-regulated cryptic exons in patient-derived neurons, and to identify and optimize small molecules that selectively bind and stabilize those structures. The research combines...
- The National Institute on Aging awarded Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, $479,579 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate synaptic and metabolic alterations associated with TDP-43 proteinopathy in amyotrophic lateral sclerosis and frontotemporal dementia. The research identifies how mislocalization of TDP-43 protein from the nucleus to the cytoplasm disrupts synaptic vesicle cycling, RNA processing,...
- The National Institute of Neurological Disorders and Stroke (NINDS) of the Department of Health and Human Services awarded Yale University $446,670 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate bi-functional helical peptides that inhibit TDP-43 aggregation. TDP-43 mislocalization and aggregation is central to amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with TDP-43...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $461,900 Project Grant to Pennsylvania State University on May 1, 2025. The grant, titled "Mechanisms Underlying TDP-43 Dependent Structural Deficits in ALS Muscles", will fund research to study the role of the TDP-43 protein in muscle degeneration associated with Amyotrophic Lateral Sclerosis (ALS). The research aims to uncover the mechanisms by which TDP-43 impacts muscle...
- The National Institute of Neurological Disorders and Stroke awarded Thomas Jefferson University $196,250 on June 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a novel diagnostic test for early detection of respiratory impairments in amyotrophic lateral sclerosis (ALS). The research addresses a critical gap in ALS care by creating a composite diagnostic score combining airway occlusion pressure...