Project Grant RF1NS145263
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, consolidates multiple research projects into a single larger R35 grant to enable comprehensive exploration of biological mechanisms underlying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's disease. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to develop a novel cellular model for investigating amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will directly convert patient-derived fibroblasts into neurons, preserving the epigenetic age of the starting cells, in order to...
- This $2,817,215 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to elucidate the role of the TRIM10 protein in maintaining the solubility and function of the TDP-43 protein. TDP-43 misfolds and aggregates in progressive neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,138,538 to Mayo Clinic Jacksonville to expand research into the mechanisms underlying frontotemporal lobar degeneration (FTLD), which causes frontotemporal dementia (FTD) and is genetically linked to amyotrophic lateral sclerosis (ALS). The research aims to investigate key...
- This federal Project Grant award of $432,802 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the genetic and molecular mechanisms underlying cognitive impairments in C9ORF72-related frontotemporal dementia (FTD). The research aims to cross-validate gene expression changes associated with TDP-43 pathology between Drosophila and human...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
- This Project Grant award of $374,349 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and optimization of a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The goal is to create a mouse model that accurately recapitulates the human disease spectrum by incorporating an acetylation-mimicking...
- This Project Grant award of $460,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate the roles of the deubiquitylation pathway in TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research is being conducted by the University of Massachusetts Medical School (UMMS) and...
- This $3,081,936 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying TDP-43 proteinopathies, which are associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease,...
- This $438,606 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research at Northwestern University to establish novel human models that investigate the mechanistic interaction between neurotrauma and amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). The research utilizes ALS/FTD patient-specific induced...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to identify genetic modifiers that contribute to phenotypic heterogeneity in the amyotrophic lateral sclerosis (ALS) - frontotemporal degeneration (FTD) spectrum. The $3,204,260 award to The Trustees of the University of Pennsylvania, effective August 1, 2025 through July 31, 2029, will leverage the institution's integrated ALS and FTD research centers to pursue two main strategies: 1) identifying polygenic modifiers of cognitive and motor traits across the ALS-FTD spectrum, and 2) exploring the genetic basis for variable prognosis, even within C9orf72 repeat expansion families. The goal is to improve prognostication and clinical trial stratification for these devastating neurodegenerative disorders by enhancing understanding of the genetic factors underlying phenotypic heterogeneity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 7/25/25 |