Project Grant R21NS148841
- The National Institute of Neurological Disorders and Stroke awarded the University of Georgia Research Foundation $1,297,188 on May 8, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neuroinflammatory epitranscriptomic mechanisms in Parkinson's disease. The research examines the role of the ALKBH5 demethylase enzyme in microglial neuroinflammatory responses triggered by alpha-synuclein aggregates, a hallmark...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $462,855 under grant R21NS147184 on September 1, 2026, to develop and characterize isogenic neuronal cell models carrying mitochondrial DNA mutations implicated in neurological diseases. The recipient will establish human immortalized neuronal cell lines and induced pluripotent stem cell–derived neurons harboring pathogenic mitochondrial DNA mutations across oxidative phosphorylation complexes I, III, IV, V,...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $129,186 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate metabolic plasticity and neuronal resilience in response to chronic mitochondrial DNA damage. The research will characterize mitochondrial DNA distribution and motility in healthy versus mitochondrial DNA-compromised neurons using two...
- The National Institute of Neurological Disorders and Stroke awarded Brandeis University $436,864 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms by which hypoxia and genetic suppressors rescue mitochondrial Complex I function. The research combines C. elegans genetics, mitochondrial biochemistry, and cryogenic electron microscopy to define the structural basis of hypoxia...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Emory University $420,142 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to explore the contribution of extracellular vesicles to epileptogenesis in temporal lobe epilepsy and Dravet syndrome. The research examines how extracellular vesicles—small membranous particles...
- The National Institute of Neurological Disorders and Stroke awarded $539,000 to Augusta University Research Institute, Inc. on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of sub-pallidal basal forebrain activation to increase acetylcholine levels in the cerebral cortex, with applications to electrical stimulation therapy currently in clinical trials. The research comprises three...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $555,000 to Augusta University Research Institute, Inc. on May 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of a novel optogenetic assay to study intracellular transport defects in neurodevelopmental diseases. The research addresses how motor...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $927,014 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to validate a diagnostic lipid biomarker panel for idiopathic Parkinson's disease. The R61 phase of this project will develop a quantitative liquid chromatography-mass spectrometry assay for eight lipid biomarkers discovered in red blood cells that distinguish idiopathic...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $214,329 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate infection-driven inflammation as a driver of neurodegeneration in primary mitochondrial diseases. The research characterizes immune dysfunction across genetic forms of human primary mitochondrial disease through immunophenotyping and functional assessment,...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Research Foundation for the State University of New York $645,070 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating mitochondrial gene regulation in central nervous system development, with focus on how the transcription...
The National Institute of Neurological Disorders and Stroke awarded $402,347 to the University of Georgia Research Foundation, Inc. on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing 93.853) to develop an extracellular vesicle-based platform for delivering healthy mitochondria to nerve cells affected by neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease. The research addresses the challenge of delivering mitochondrial transplants across the blood-brain barrier to the central nervous system. Preliminary data show that co-incubation of extracellular vesicles derived from neural progenitor cells with isolated mitochondria significantly enhances mitochondrial uptake by neural cells in vitro and brain accumulation in vivo following intranasal administration. The project leverages the neuroprotective and regenerative properties of neural progenitor cell-derived extracellular vesicles, combined with bioenergetic benefits of healthy mitochondria, to improve central nervous system targeting and therapeutic efficacy in preclinical models of neurological disease. Work is performed in Athens, Georgia. The period of performance extends from September 2, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $402.3k | 9/2/26 |