Project Grant R21NS147222
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Beth Israel Deaconess Medical Center $749,073 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate meningeal sensory neuroimmune interactions underlying migraine headache. The research combines expertise in meningeal nociception and migraine pain with functional interactions between nociceptors...
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. (BIDMC) was awarded $475,475 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 1, 2025, through June 30, 2027. The research project investigates the pathophysiology of morning migraine—migraines characterized by symptom onset between 3–6 AM—with a focus on the relationship...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital $745,570 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the genome-wide association study (GWAS) based neurovascular etiology of migraine and its associated risk of ischemic stroke. The research addresses the gap between recent genetic discoveries identifying 123 migraine susceptibility loci and...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3.833 million on July 22, 2026, to investigate the role of TRP ion channels in migraine pain under the Drug Use and Addiction Research Programs (CFDA 93.279). The research examines how TRPV4 calcium ion channels in meningeal mast cells and satellite glial cells contribute to migraine pain and how this contribution varies by sex. The project employs trigeminal neuron–mast cell co-culture techniques, mast cell and...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Massachusetts Institute of Technology $129,168 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on the modulation of autonomic function by affective pain pathways. The research interrogates the role of the parabrachial-limbic circuit and...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center $475,475 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of neurotensin-expressing neurons in the lateral hypothalamus in narcolepsy with cataplexy pathophysiology. The research examines whether enhancing lateral hypothalamic neurotensin neuron activity mitigates sleepiness and cataplexy...
- The National Institute of Neurological Disorders and Stroke awarded the Trustees of Boston University $170,132 under Project Grant F31NS145737 on December 1, 2025, to support research on the regulation of cerebral blood flow by intrinsic neuromodulation across wakefulness and sleep states. The award is made under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will examine neurovascular coupling through two coordinated aims....
- The National Institute of Neurological Disorders and Stroke awarded Dartmouth-Hitchcock Clinic $426,250 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate translaminar interneurons in the spinal cord dorsal horn and their role in the transition from acute to chronic pain. The research combines voltage imaging, electrophysiological, and histological strategies to study excitatory translaminar interneurons in...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during...
The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center, Inc. $283,037 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds exploratory research investigating the relationship between meningeal nociception and visual cortex hyperexcitability in migraine pathogenesis. The project employs optogenetic activation of meningeal nociceptors, two-photon calcium imaging of visual cortex activity, and optogenetic cortical spreading depolarization triggering in transgenic mice to test whether repeated meningeal nociceptor activation promotes visual cortex hyperexcitability and increased susceptibility to cortical spreading depolarization through dural T cell-to-cortex signaling. The research addresses the proposed feedforward mechanism whereby meningeal nociception drives visual cortex hyperexcitability across multiple migraine attacks, incorporating immunological pathways mediated by T cell cytokine production in the cranial dura mater. Performance occurs at Beth Israel Deaconess Medical Center in Boston, Massachusetts, with a period of performance from August 15, 2026, through July 31, 2028. The award carries assistance type designation of Project Grant, a mechanism supporting investigator-initiated research within NINDS's mission to support fundamental neuroscience research and reduce the burden of neurological disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $283.0k | 8/6/26 |