Project Grant R01NS146933
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, with a completion date of July 31, 2027. The award supports research investigating post-ischemic protection of white matter (WM) following ischemic stroke, addressing...
- The National Institute of Neurological Disorders and Stroke awarded Oregon Health & Science University $619,833 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to decode PARP7 marylation-ubiquitylation crosstalk in neuronal health and disease. The research will identify neuronal PARP7 substrates and marylation sites using chemical-genetic proteomics; establish the enzymatic machinery (writers, extenders, and...
- The National Institute of Neurological Disorders and Stroke awarded Oregon Health & Science University $536,121 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for Project Grant R01NS144584. The award funds research into the metabolic basis for oligodendrocyte-vascular interactions in white matter development and injury, with focus on neonatal white matter injury resulting from hypoxia-ischemia in preterm and...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded The Ohio State University $180,240 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the mechanisms by which the neuronal TRPM2 ion channel affects post-stroke cognitive impairment. The project uses genetic animal models and adeno-associated viruses to conditionally knockout...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas at Austin $393,284 on June 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on synaptic structural plasticity and stroke rehabilitation. The project examines how the brain remodels neural circuitry following stroke, with focus on reactive synaptogenesis—the growth of new connections among surviving neurons near...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Oregon Health & Science University $507,491 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 12, 2026. The award funds investigation into the mechanistic basis of astrocyte-neuron signaling during neuronal remodeling in the developing brain. The research uses Drosophila models to understand how...
- The National Institute of Neurological Disorders and Stroke awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $616,031 on May 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate arterial endothelial pannexin 1 channels in ischemic stroke-induced vascular dementia, with specific focus on age and sex differences. The research examines the role of cerebral endothelial pannexin 1 (PANX1)...
- The National Institute of Neurological Disorders and Stroke awarded the University of California Irvine $863,500 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of vascular contributions to cognitive impairment and dementia due to cerebral microbleeds in the context of periodontitis. The project uses novel animal models of cerebral microhemorrhage to identify mechanisms linking dementia...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $435,550 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing). The award funds investigator-initiated research examining the role of DNA methyltransferase 3 alpha (DNMT3A) in oligodendrogenesis and white matter repair following ischemic stroke. The project tests the...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $433,125 to the University of Texas Health Science Center at San Antonio on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of REST (Restrictive Element-1 Silencing Transcription Factor) in governing post-stroke neural plasticity and recovery. The...
The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $594,435 to Oregon Health & Science University on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on pericyte phenotypic switching in diabetic post-stroke cognitive impairment. The project, R01NS146933, investigates the cellular and molecular mechanisms underlying post-stroke cognitive impairment in diabetic patients. The research tests the hypothesis that communications between pro-inflammatory pericytes and microglia under diabetic conditions contribute to cognitive decline following stroke, driven by loss of endothelial-pericyte signaling. The work will determine whether endothelium-derived epoxyeicosatrienoates acting on pericyte G protein-coupled receptor GPR39 provide protection against post-stroke cognitive impairment, and whether disruption of this signaling pathway in diabetes—caused by endothelial upregulation of soluble epoxide hydrolase—induces pro-inflammatory changes in pericytes and microglia. Aim 1 uses mice with inducible deletion of endothelial soluble epoxide hydrolase to test protection against diabetic post-stroke cognitive impairment in an age- and sex-dependent manner. Aim 2 employs single-cell RNA sequencing to analyze pericytes and microglia from diabetic and nondiabetic mouse brain after stroke to identify pericyte and microglial subtypes and genes involved in cell-cell interactions contributing to cognitive impairment. Place of performance is Portland, Oregon 97239. The period of performance runs from August 15, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $594.4k | 8/14/26 |