Project Grant R21NS146921
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas at Austin $393,284 on June 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on synaptic structural plasticity and stroke rehabilitation. The project examines how the brain remodels neural circuitry following stroke, with focus on reactive synaptogenesis—the growth of new connections among surviving neurons near...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $617,439 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to examine how lesion location and extent affect post-stroke neuroplasticity and recovery mechanisms. The project will use rat stroke models with varying lesion sizes and locations—systematically manipulating damage to the corticospinal tract and lesions in the cortex...
- The National Institute of Neurological Disorders and Stroke awarded the University of Wisconsin–Madison $494,240 on February 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate target-directed microRNA degradation in post-stroke brain tissue. The project examines how microRNA-7 is depleted following stroke despite intact biogenesis, hypothesizing that target-directed microRNA degradation (TDMD) drives this loss....
- The National Institute of Neurological Disorders and Stroke awarded Northern California Institute For Research And Education, Inc. (NCIRE) $414,464 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on sleep-dependent modulation of transplanted neural circuits for stroke recovery. The project characterizes the integration of human induced pluripotent stem cell (iPSC)-derived neurons transplanted...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas at Austin $541,700 on June 12, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop quantitative three-dimensional imaging techniques for measuring cerebral blood flow during stroke. The project develops two new methodological advances to laser speckle contrast imaging (LSCI). The first advance uses within-exposure laser intensity...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas Health Science Center at Houston $619,975 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining the interaction of X chromosome and sex hormonal effects in stroke and neuroinflammation in postmenopausal women. The project investigates why stroke incidence and severity increase in women after...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $594,435 to Oregon Health & Science University on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on pericyte phenotypic switching in diabetic post-stroke cognitive impairment. The project, R01NS146933, investigates the cellular and molecular...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $435,550 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing). The award funds investigator-initiated research examining the role of DNA methyltransferase 3 alpha (DNMT3A) in oligodendrogenesis and white matter repair following ischemic stroke. The project tests the...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded the University of Pennsylvania $703,249 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, assistance type: Project Grant, award number R01NS141408). The funded work integrates large-scale proteomics and genomics to characterize ischemic stroke risk factors and biological pathways. The research scans 6,432...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $642,712 to The University of Texas Southwestern Medical Center on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate adult neurogenesis as a strategy for improving urinary function after contusion spinal cord injury. The project systematically examines...
The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $433,125 to the University of Texas Health Science Center at San Antonio on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of REST (Restrictive Element-1 Silencing Transcription Factor) in governing post-stroke neural plasticity and recovery. The project, R21NS146921, addresses stroke as a leading cause of adult disability affecting more than 800,000 people annually in the United States, with over half of survivors living with chronic motor impairments. The research team will use a transgenic mouse model to test the hypothesis that REST restricts adult stroke recovery by suppressing developmental plasticity genes. Prior work by the team developed SpinalTraq, an imaging and analysis platform enabling high-resolution mapping of post-stroke spinal cord connectivity, and identified axonal sprouting from the uninjured corticospinal tract generating new synaptic connections within denervated spinal cord. Transcriptomic analysis revealed activation of neuronal growth pathways characteristic of immature brain, normally repressed in adults by REST. Work is performed in San Antonio, Texas. The performance period runs from August 1, 2026, through July 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 7/24/26 |