This Project Grant award of $427,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the University of Iowa to investigate the mechanisms underlying lithium's therapeutic benefits and adverse effects. The key focus is on elucidating the role of proline metabolism, particularly through the lithium-inducible SLC6 transporter, in modulating susceptibility to lithium's adverse neurological impacts. The research leverages Drosophila genetics and physiology to explore the molecular and cellular processes involved, with the goal of enhancing understanding of lithium's effects and informing improved treatment approaches for nervous system disorders. The award period runs from Jul 4, 2025 to Jun 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $427.6k | 7/4/25 |