This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate impairments in membrane trafficking in Fragile X Syndrome (FXS). The $430,375.00 award to Emory University, with a project period from July 1, 2025 to June 30, 2027, will test the hypothesis that increased levels of the clathrin-associated adaptor complex protein-2 (AP2) lead to reduced surface expression of AMPA receptors and other membrane proteins, contributing to synaptic development and functional impairments in FXS. The research aims to elucidate the underlying mechanisms by which the loss of the fragile X mental retardation protein (FMRP) impacts membrane protein trafficking, with potential implications for developing therapeutic strategies targeting AP2 to correct these deficits in FXS and other neurodevelopmental disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $430.4k | 6/25/25 |