This $241,500 Project Grant award from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) aims to understand the molecular mechanisms governing lymphatic dysfunction in a mouse model of neurodevelopmental disorder, specifically Fragile X syndrome. The key objectives are to: 1) determine how the FMR1 gene regulates meningeal lymphatic function, 2) decipher the role of FMR1-induced lymphatic dysfunction in interferon-gamma T cell maintenance, and 3) address the contribution of meningeal lymphatic dysfunction to Fragile X-associated social behavior.
The research will be conducted by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, a private university with experience in receiving federal research grants. The award period extends from December 2024 to November 2029, aiming to advance the understanding of lymphatic regulation in neurodevelopmental disorders and identify potential new therapeutic targets.
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