This $438,342 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to illuminate the mechanisms by which ubiquitin ligases regulate protein complexes involved in chromatin regulation and neurodevelopment. The primary objectives are to: 1) Dissect the interaction between the Anaphase-Promoting Complex (APC) ubiquitin ligase and...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $164,998 to the University of North Carolina at Chapel Hill to conduct research on the neural circuit mechanisms underlying seizure susceptibility in a mouse model of Angelman syndrome.
The key objectives of this 2.5-year research project are to: 1) determine how the intrinsic firing...
The federal Project Grant award R41NS134480, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding Couragene, Inc. to develop a novel, chemically modified ribonucleoprotein (CRNP) delivery system for CRISPR-based gene editing to treat Angelman syndrome. The $339,999 award supports formulation optimization of the CRNP to achieve over 70% editing...
This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop a novel enzyme delivery system for treating neuronopathic Gaucher disease (NGD).
The $653,309 award will fund the development and evaluation of a brain-targeted SAPC-DOPS nanocarrier loaded with a stable form of the deficient enzyme acid β-glucosidase...
The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $443,121 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of California Santa Cruz. This two-year grant, with a period of performance from July 1, 2024 to June 30, 2026, will leverage innovative in situ cryo-electron microscopy (cryo-EM) techniques to study dysregulated protein synthesis, or translation, in an autism spectrum...
Emory University received a $430,375 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to elucidate the subcellular dynamics of ubiquitination, a key biological process regulating synaptic function and neuronal health, using advanced single-molecule imaging techniques. The research aims to uncover new mechanisms by...
This $193,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support the development of a novel synthetic biology platform at Stanford University. The platform will consist of an inducible and multiplexed dual gene modulation system capable of simultaneous and sequential gene activation and suppression in human induced pluripotent stem...
This $299,978 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of novel molecular glue degraders for the LRRK2 protein. The award supports Lifesensors Inc., a biotechnology company that specializes in ubiquitin and ubiquitin-like protein research tools and services, to develop a high-throughput ubiquitination assay. This assay will enable the rational design of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $419,038 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of North Dakota (UND) from September 17, 2024 to August 31, 2027.
The goal of this grant is to develop a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging of neural activity, including astrocytes, in freely behaving mice....
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the potential of genetically-targeted therapies for autism spectrum disorder (ASD) and other neurodevelopmental disorders caused by mutations in epigenetic "writer" enzymes. The $272,125 award to The Washington University in St. Louis will enable the...