Project Grant R21NS142816
- The National Institute of Neurological Disorders and Stroke awarded $466,021 to Weill Medical College of Cornell University on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and evaluate ACCENT (Acyclovir-Controlled Calcium Entry Neuromodulation Tool), a novel RNA-based platform for selective modulation of L-type voltage-gated calcium channels to treat chronic pain and reduce opioid dependence. The research addresses the clinical problem of...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $589,156 on February 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates s-palmitoylation as a regulatory mechanism for CAV2.1 and CAV2.2 calcium channels in presynaptic neurons. These channels mediate calcium influx that triggers neurotransmitter release at chemical synapses and...
- The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $603,264 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate endothelial sphingolipid signaling in cerebrovascular inflammation and cognitive decline. The project examines how sphingosine-1-phosphate receptor signaling in cerebrovascular endothelial cells regulates blood-brain barrier function...
- The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $635,074 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop HCN1-selective nanobodies for use in novel, non-opioid antihyperalgesia therapeutics targeting neuropathic pain. The project focuses on creating an HCN1-selective nanobody and identifying critical geometric features of the human HCN1 ion channel to guide antibody-drug conjugate...
- The National Institute of Neurological Disorders and Stroke awarded Rosalind Franklin University of Medicine & Science $396,015 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support molecular characterization of genes regulating CAV2 voltage-gated calcium channels and their roles in channel trafficking and degradation. The research uses C. elegans as a model organism to identify and characterize genes...
- The National Institute of Neurological Disorders and Stroke awarded New York University $466,125 on September 25, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop genetic approaches for studying the organization and function of neocortical layer 1. The research examines how top-down information streams (behavioral saliency, expectations, predictions, and memories) integrate with bottom-up sensory information in the...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $264,250 on May 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a cre-intersectional viral method for precise opto- and chemo-genetic inactivation of specific cortico-cortical projection pathways in awake non-human primates. The funded research addresses a fundamental challenge in neuroscience: achieving...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $198,164 to Weill Medical College of Cornell University on September 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of heme in oxidative modification of mRNA in neurodegenerative disease. The research examines how heme binds to G-quadruplex sequences...
- The National Institute of Neurological Disorders and Stroke awarded $539,000 to Augusta University Research Institute, Inc. on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of sub-pallidal basal forebrain activation to increase acetylcholine levels in the cerebral cortex, with applications to electrical stimulation therapy currently in clinical trials. The research comprises three...
- The National Institute of Neurological Disorders and Stroke awarded $198,728 to The Trustees of Columbia University in the City of New York on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research quantifying relationships between behavior, neural network activity, and metabolic dysfunction in a genetic mouse model of developmental epileptic encephalopathy. The investigator will measure behavior and...
The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $466,125 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to develop and benchmark ACCENT (Acyclovir-Controlled Calcium Entry Neuromodulation Tool), a chemogenetic platform for selective, reversible, and dose-dependent control of L-type calcium channels in neurons using the FDA-approved drug acyclovir. The research combines an acyclovir-controlled splicing-based gene expression switch with genetically encoded L-type calcium channel modulators to directly enhance or suppress calcium signaling in targeted neurons, addressing limitations of existing chemogenetic tools such as DREADDs that indirectly regulate calcium signaling and do not replicate the rapid, graded calcium dynamics underlying synaptic plasticity. The recipient will benchmark ACCENT against DREADDs in mouse hippocampus, test its ability to regulate memory formation and downstream plasticity-related gene expression, and generate comparative data on cell-specific calcium regulation effects on hippocampus-dependent learning and memory. The platform uses widely available AAV vectors, common laboratory equipment, and commercially available reagents. Findings are intended to accelerate targeting of L-type calcium channels in maladaptive conditions and inform understanding of circuit dysfunction in cognitive disorders; L-type calcium channels are implicated in schizophrenia and autism. Performance occurs at Weill Medical College in New York, New York, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $466.1k | 8/14/26 |