Project Grant R21NS141110

Award Date 9/20/24
Completion Date 9/19/26
Dollars Obligated $481K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02138, USA
Similar Awards
This Project Grant award of $385,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a novel inducible and multiplexed dual gene regulation CRISPR system to study neuronal activity and regeneration. The award will fund research at The Leland Stanford Junior University (Stanford University) to engineer a system capable of simultaneous...
This Project Grant award of $270,434, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Princeton University to investigate the spatiotemporal regulation of mRNA and its role in neuronal remodeling during morphogenesis. The project will leverage Drosophila models to characterize the localization and motility of the chickadee (chic)...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,503,949 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rockefeller University. The grant, awarded on May 1, 2025, supports a research project titled "Applying RNA Logic in Space and Time to Neurologic Disease". The project aims to develop new techniques and concepts to discover therapeutic targets for neurological diseases by studying...
This Project Grant award of $244,154, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Albert Einstein College of Medicine to investigate the regulation of presynaptic gene transcripts during synaptogenesis. The research, conducted over the period from September 1, 2024 to June 30, 2027, will leverage the genetic accessibility and...
This federal Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $1,330,000.00 to The Salk Institute for Biological Studies to develop a genetically encoded system for the targeted degradation of extracellular proteins (TDEP) in the brain. The goal is to use TDEP to transiently enhance neuronal plasticity, enabling controlled synaptic remodeling and repair. The project will determine if acute degradation of specific...
This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
This $563,343 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports research conducted by New York University (NYU) to investigate the physical, molecular, and cellular mechanisms underlying tissue guidance and tissue splitting during nervous system development. The research uses the posterior lateral line primordium migration in zebrafish as...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to develop a chemical strategy for light microscopy-based imaging of neural synapses and circuit connectivity in post-mortem specimens, including potentially the human brain. The $235,887 award, with a project period from April 1, 2025 to March 31, 2027, will be...
This Project Grant award, valued at $412,525.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research focused on the molecular mechanisms that regulate ADAR target recognition and RNA editing. The award will fund an integrated research approach using human cell lines and the model organism Caenorhabditis elegans to investigate how ADAR binding to target RNAs is influenced by...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...

This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and stage-specific neuronal circuitry, in order to discover RNAs and proteins that control the organization, precision, and function of distinct neural circuits, and how they are dysregulated in disease. The award will fund the development of systems for subcellular manipulation of molecular abundances in developing and mature circuits, with potential applications toward novel, uniquely specific forms of therapeutics and bioactive delivery.

Generated 7/15/25, 3:07 AM