This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to investigate the pathophysiology of morning migraine. The $475,475 award to Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to test the hypothesis that circadian-driven complement activation and aberrant purinergic responses are key triggers of morning...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $162,486 to the University of Illinois to conduct research on the relationship between sleep disturbances, menstrual cycle, and acute suicide risk. The study will leverage high-resolution digital health sleep data and hormone measurements from a previously completed clinical trial to examine how sleep patterns and menstrual cycle phases may...
This $792,441 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to investigate the dynamic trajectory of behavioral, physiological, and neurobiological stress responses in female adolescents at high and low familial risk for depression. The key objectives are to: 1) Track changes in default mode network (DMN) and central executive network (CEN) dynamic properties from before to after an acute psychosocial...
The federal Project Grant award K23MH136325 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will provide $196,776 to the Emma Pendleton Bradley Hospital, doing business as Bradley Hospital, to conduct research on the effects of ovarian steroids on mood and sleep in adolescent females. The study will characterize hormone sensitivity in 50 female adolescents aged 11-14 years by collecting daily assessments of mood, sleep, and...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $904,100.00 to the Lovelace Biomedical Research Institute to conduct a longitudinal study on predicting mental health outcomes and related factors in incarcerated women. The project aims to develop machine learning algorithms that utilize multimodal data, including psychosocial, forensic, and neuroimaging variables, to identify brain...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $919,453 to the Van Andel Research Institute (VAI) to study the immunobiological mechanisms underlying depression during the perimenopause transition in women. The study aims to identify plasma tryptophan metabolite and cytokine patterns, epigenetic mechanisms in lymphocytes, and inflammatory and metabolic markers that may contribute to...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $537,035 to The Mclean Hospital Corporation in Belmont, MA to conduct a multilevel characterization of sensory cortical disinhibition in post-traumatic intrusions. The research aims to link lower levels of inhibitory neural activity and neurotransmitter imbalances to perturbations in resting-state neural network dynamics, and connect this...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,755,796.00 to the Icahn School of Medicine at Mount Sinai to conduct research on the hormonal drivers of perimenopausal inflammation and mood symptoms. The goal is to compare the time course of changes in reproductive hormones, acyl-ghrelin, inflammation, and mood symptoms in women undergoing surgical menopause. The study aims to test...
This Project Grant award of $535,153 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of molecular and cellular networks involved in mood regulation in major depressive disorder (MDD). The project aims to identify transcriptomic changes associated with MDD in a sample of 800 subjects across three key brain regions: the anterior cingulate cortex, basolateral amygdala, and...
This federal Project Grant award, valued at $175,647.00 and awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the relationship between positive childhood experiences, prenatal biobehavioral resilience, and postpartum mental health and well-being. The key objectives of this 5-year project are to: 1) examine how positive childhood experiences are associated with physiological and self-reported...