Project Grant K01MH136417

Award Date 9/5/24
Completion Date 8/31/28
Dollars Obligated $370K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Boston, MA 02115, USA
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This $370,440 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research by Brigham & Women's Hospital, Inc. to characterize the longitudinal relationship between migraine and affective disorders across the lifespan, with a focus on hormonal fluctuations. The research objectives include:

  1. Determining the longitudinal association between migraine and affective disorders, emphasizing hormonal transitions, using data from the Nurses' Health Study cohorts.

  2. Estimating the relationship between migraine (menstrual and overall) and premenstrual syndrome/premenstrual dysphoric disorder using smartphone data and ecological momentary analysis in the Nurses' Health Study 3 and Growing Up Today Study cohorts.

  3. Collecting data on affective disorder symptom variability across the menstrual cycle among migraineurs compared to non-migraineurs.

The project aims to establish migraineurs as a unique phenotype of individuals with affective disorders due to their vulnerability to hormonal fluctuations, which could improve risk assessment, screening, and treatment for this comorbidity. The award period is from September 5, 2024 to August 31, 2028.

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