Project Grant R21NS139338
- This Project Grant award for $735,373, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to advance the development of pantothenate kinase (PANK) activators as a potential therapy for pantothenate kinase-associated neurodegeneration (PKAN). The award will fund the development of the next generation of PANK activators to overcome the...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The $1,009,212 award to the Van Andel Research Institute in Grand Rapids, MI will fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to enhance the activity of the...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding the development of a novel diagnostic assay for Parkinsonian tauopathies. The $446,991 award, made on Aug 7, 2025, supports the creation of aptamer-based ELISA assays to detect two tau peptides that can distinguish progressive supranuclear palsy (PSP) from corticobasal...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $231,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Rochester. The grant, which runs from March 1, 2025 to January 31, 2028, aims to develop culturally-tailored approaches to improve equity in palliative care research and service delivery for individuals with Parkinson's disease, Lewy body dementia, and related disorders living...
- This federal Project Grant award of $342,002.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at Western Michigan University Homer Stryker M.D. School of Medicine (WMED) to develop novel cellular tools for studying the regulation of the PKD1 gene in autosomal dominant polycystic kidney disease (ADPKD). The research aims to...
- This federal Project Grant award of $169,000 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) will support the development of a comprehensive, open-source, and user-friendly online platform for neurometabolic diseases. The platform will include clinical, biochemical, radiological, and therapeutic data on over 1,600 known neurometabolic diseases. This initiative aims to enhance understanding, clinical management, and research insights into these rare genetic...
- This $769,995 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Northwestern University to investigate the functional genetic basis of KCNB1 encephalopathy. This rare and severe neurodevelopmental disorder is characterized by developmental delay, intellectual disability, seizures, and elevated mortality risk. The research aims to...
- This Project Grant award of $422,125 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the fundamental roles of the DNAJC12 protein in dopamine production and brain function. The research aims to specifically ablate DNAJC12 in dopaminergic neurons in order to ascertain the effects of this gene dysfunction on dopamine synthesis,...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research to understand the molecular mechanisms underlying BK potassium channel dysfunction in neurological disorders. The $655,968 grant, awarded on April 21, 2025, will be used by researchers at Washington University to conduct a multi-year study investigating how...
- This Project Grant award of $255,343 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a study examining the effects of elevated phenylalanine levels on metabolic, neurophysiologic, and cognitive functioning in adults heterozygous for phenylketonuria (PKU). The study will conduct a double-blind crossover investigation involving 18 genetically-confirmed PKU carriers and 18...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of genetic testing and counseling for Pantothenate Kinase-Associated Neurodegeneration (PKAN) in the Dominican Republic. The $347,767 award, with a performance period from August 20, 2025 to August 19, 2027, aims to establish a process for genetic testing and counseling for this rare, autosomal recessive neurological disorder in an isolated region of the country where multiple affected individuals and families have been identified. The project will be carried out by the Trustees of Columbia University in the City of New York, through its Health Sciences Division.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $347.8k | 8/19/25 |