Project Grant R21NS139257
- This $580,619 Project Grant was awarded on August 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate the molecular mechanisms underlying the pharmacological activation of KCa2 potassium channels, which are important for regulating neuronal excitability in the central nervous system. The research aims to: 1) Compare...
- This federal Project Grant award, valued at $238,276, was provided by the National Institute of Neurological Disorders and Stroke under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The funding supports research at the University of California, Irvine to investigate the role of the enzyme N-acylethanolamine acid amidase (NAAA) in the development of hyperalgesic priming, a model for studying the transition from acute to chronic pain. The project aims to identify the receptor...
- This $4,039,366 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), will support a research project titled "A Fully Humanized Functional Genomic Screen to Identify and Validate Pain Therapeutic Targets" under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279). The project will leverage innovative CRISPR-based screening and human dorsal root ganglion (DRG) transcriptomic data to...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research by Function Therapeutics Inc. to investigate the use of a new class of small molecule compounds called Parmodulins for the treatment of neuropathic pain. The $499,863 award, granted on September 11, 2025, will fund research to synthesize and test various Parmodulins for their ability to modulate the...
- This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
- This federal Project Grant award of $231,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to overcome challenges in targeting specific acid-sensing ion channel (ASIC) subunits and heteromers for analgesic treatments. The key products and services to be delivered include: 1) Identifying a novel binding site for the ASIC3 inhibitor ApetxT2 using...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $650,079 Project Grant to Northeastern University under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports the development and optimization of novel small-molecule probes targeting the alpha9 nicotinic acetylcholine receptor (α9*-nAChR) subunit, with the goal of exploring its potential for pain management. The 5-year project aims to advance...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $664,772 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Texas Southwestern Medical Center. The grant supports research to investigate the mechanisms by which the neurotensin receptor 2 (NTSR2) interacts with calcium channels as a potential non-opioid analgesic mechanism for treating chronic pain. The project involves characterizing...
- This federal Project Grant award of $222,758 from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research to map the functional roles of different neuron types in the dorsal root ganglia (DRG) and understand their contributions to pain perception in the brain. The primary awardee, the University of North Carolina at Chapel Hill (UNC-CH), will use innovative optogenetic and chemogenetic techniques to selectively...
This $407,113 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to develop new potassium channel modulators to reduce neuronal overexcitation and mitigate chronic pain. The award, granted to the University of California, Irvine, funds research to identify and validate compounds that can stabilize the interaction between potassium channels and an essential cofactor, thereby preventing the suppression of the M-current that normally counteracts action potential generation and neuronal excitability. This work builds on the grantee's prior research using mutant potassium channel mice, which demonstrated reduced inflammatory pain. The project will leverage a novel in silico screening process to identify promising compounds and functionally verify their ability to attenuate receptor-induced potassium channel current suppression through electrophysiological experiments. If successful, this research could lead to the development of new pain therapies targeting neuronal excitability.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $407.1k | 8/4/25 |