This federal Project Grant award, provided under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program administered by the National Institute of Neurological Disorders and Stroke (NINDS), aims to define the pathobiological trajectory of early-onset neurological disorders in relation to methylglyoxal, microvascular leakage, and inflammation in HIV-1 infected humanized mouse models. The $652,375 award will also assess whether lowering...
The University of California, Los Angeles (UCLA) was awarded a $415,876 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) by the National Institutes of Health Office of the Director, with a performance period from August 1, 2024 to July 31, 2026. The purpose of this grant is to optimize and utilize a novel five-dimensional (5D) magnetic resonance spectroscopic imaging (MRSI) technique called "ROSE-JRESI" and three-dimensional myelin water imaging (MWI) to study...
This federal Project Grant award of $1,454,724 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The award aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, which are considered viral reservoirs in the...
This Project Grant award for $665,171.00, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to improve outcomes for individuals with HIV-associated opportunistic infections like cryptococcal and TB meningitis. The key objectives are to: 1) define CSF drug concentrations or AUC/MIC ratios that predict fungal clearance, 2) determine the relationship between...
This $197,345 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to examine how tunneling nanotubes (TNTs) facilitate the spread of HIV infection and associated neurodegeneration within the central nervous system. The principal investigator, Dr. Valdebenito-Silva, will investigate the mechanisms by which HIV induces...
This $396,541 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to uncover fundamental mechanisms and key features governing the interactions between antiretroviral drugs (ARVs) and the blood-brain barrier (BBB) components. The overall goal is to improve the ability of ARVs to penetrate and treat HIV infection in the brain. The University of Colorado, as the prime awardee, will employ a physiologically...
This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,332,155 to Emory University to conduct research focused on developing immunotherapies to cure HIV in SHIV-infected infant macaques. The key objectives are to evaluate strategies that leverage broadly neutralizing antibodies (bNAbs) in combination with virus reactivation, innate immune stimulation, and attachment...
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
This $823,691 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the role of immune checkpoints in the central nervous system (CNS) of people living with HIV (PLWH) and their association with HIV-associated neurocognitive disorder (HAND). The research aims to determine the profiles and biological functions of soluble immune checkpoints (sICPs) in the CNS of PLWH and a simian immunodeficiency...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $843,177 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of California, Los Angeles (UCLA) to evaluate the efficacy of broadly neutralizing antibodies (BNABs) encapsulated in nanotechnology-based "nanocapsules" for targeting central nervous system (CNS) HIV infection in infants.
The research aims to improve the delivery of BNABs to the CNS to suppress viremia and clear viral reservoirs, which is a critical issue for infants with HIV due to the potential for neurodevelopmental consequences. UCLA will collaborate with the Oregon Health & Science University (OHSU) on non-human primate studies to assess the pharmacokinetics and antiviral effects of the nanocapsule-delivered BNABs in the CNS. The project is expected to run from September 2024 through August 2029.