This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $433,125 to The University of Texas Health Science Center at San Antonio to conduct research on how the RNA-binding protein SERBP1 regulates epigenetic factors and gene expression in glioblastoma (GBM). The key objectives of this 2-year project are to: 1) use genomic analyses to determine SERBP1's impact on gene expression through modulation of epigenetic regulation, examining its connections to methionine levels, histone methylation, and neuronal differentiation genes; and 2) establish the mechanism by which SERBP1 regulates the translation of chromatin remodeling factors. The project aims to integrate these findings to define how SERBP1-mediated epigenetic regulation contributes to GBM development and cell fate decisions. This research seeks to elucidate novel connections between RNA-binding proteins and epigenetic factors, with the goal of identifying potential therapeutic targets for this deadly brain cancer.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $433.1k | 5/27/25 |