This $449,203 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the interaction between glioblastoma (GBM), the most malignant brain tumor, and the subventricular zone (SVZ) neurogenic niche. The research seeks to identify the specific protein components driving the increased malignancy of GBMs located in proximity to the lateral ventricles. Novel cell-specific proteomic and transcriptomic approaches will be utilized to enhance understanding of the mechanisms underlying the interplay between brain tumors and the SVZ neurogenic niche. The research aims to ultimately identify new therapeutic targets to improve survival of patients with GBM. The award period is from Sep 1, 2024 to Aug 31, 2029 and is held by Mayo Clinic Jacksonville, a nonprofit healthcare organization.
Generated 3/4/25, 7:27 AM