Project Grant R01NS134724

Award Date 9/20/24
Completion Date 8/31/29
Dollars Obligated $574K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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  • Conducting studies using patient-derived cell cultures, organoids, and xenograft models to determine the molecular mechanisms by which selective amino acid catabolism regulates glioblastoma growth and immune system interactions.
  • Evaluating dietary interventions that manipulate amino acid levels as potential novel treatment approaches for glioblastoma, including in combination with targeted therapies and immunotherapies.
  • Laying the scientific foundation for improved understanding of tumor metabolism and its implications for brain tumor biology, with the goal of translating these insights into advancements in oncological care.

The research activities are being led by the University of Pittsburgh, a major recipient of federal grants and contracts across various scientific and medical disciplines.

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