This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the federal Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the feasibility of cell-type specific modulation of the blood-brain barrier (BBB) using a novel "MagnetoBBB" approach. The total award amount is $447,501.00 with a project period from September 1, 2024 to August 31, 2026. The key objectives are to: 1) Investigate and optimize BBB control using a human brain microvascular endothelial cell line in vitro, including characterizing calcium signaling and measuring changes in electrical resistance and permeability across the cell monolayer; and 2) Study the ability to control BBB permeability in the rodent brain in vivo by delivering FERIC genes into microvascular endothelial cells and investigating the magnetic field requirements. The project leverages the University of Texas at Dallas as the primary grantee and includes a $74,756.00 sub-award to the University of California, Berkeley to develop FERIC plasmids and conduct in vitro/ex vivo experiments.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $447.5k | 8/5/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
24012185S | The Regents Of The University Of California | Project Grant R21NS135529 | $78.0k | 9/1/24 |