Project Grant R21NS133638
Award Date
9/15/23
Completion Date
8/31/25
Dollars Obligated
$430K
Federal Agency
National Institute of Neurological Disorders and Stroke
Awardee
Emory University (S352L5PJLMP8)
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
Similar Awards
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,750.00 to Emory University to conduct research on the activation of the GPR123 adhesion G protein-coupled receptor by steroid ligands. The research aims to pharmacologically characterize steroid binding to GPR123, assess signaling pathways, and elucidate the structural...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
This federal Project Grant award of $430,375.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at Emory University to investigate the role of the kinesin-3 motor protein KIF1C in regulating RNA transport and localization in neurons. The goal is to develop a human neuronal disease model for hereditary spastic paraplegia type 58 (SPG58), a...
Emory University received a $430,375 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to elucidate the subcellular dynamics of ubiquitination, a key biological process regulating synaptic function and neuronal health, using advanced single-molecule imaging techniques. The research aims to uncover new mechanisms by...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on studying the effects of the NR2E1 mutation on cellular and molecular determinants of neurogenesis. The $242,310 award to Baylor College of Medicine will support research to assess how the I385T mutation in the NR2E1 gene affects its function and ability to regulate...
This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and characterize...
This Project Grant award, valued at $396,031, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding supports research by the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to map the subcellular distribution of heterotrimeric G proteins in cardiomyocytes and neurons. The goal is to improve...
The Department of Health and Human Services, National Institutes of Health (NIH) awarded a $1,349,865 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Vanderbilt University. The grant, titled "Illuminating the Molecular Logic of Mammalian Synaptic Circuit Assembly," will fund a multidisciplinary research project to investigate the biological functions and signaling mechanisms of Adhesion G Protein-Coupled Receptors (AGPCRs) and their role in the assembly of...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders provides $532,381 to Emory University to comprehensively investigate the molecular mechanisms underlying the role of the KIF5A gene variant KIF5ADE27 in the pathogenesis of amyotrophic lateral sclerosis (ALS). The key research objectives include: 1) determining the gain-of-function effects of KIF5ADE27...
This Project Grant award of $424,338.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to elucidate the mechanisms of ependymal ciliary signaling. The primary focus is to define the complement of G protein-coupled receptors (GPCRs) expressed in ependymal cilia and determine how GPCR activation impacts cilia beating and...