This federal Project Grant award of $377,875 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop a "one-two punch" strategy using engineered extracellular vesicles (EVs) to protect the blood-brain barrier (BBB) and improve outcomes in stroke. The primary goals are to: 1) deliver ATP5A and HSP27 proteins via the EVs to increase endothelial...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
This federal Project Grant award, valued at $492,749.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS), supports the development of a novel non-invasive magnetic resonance imaging (MRI) technique called ratiometric dual contrast (RDUAL) pH-weighted MRI. The goal is to create an imaging tool that can accurately map the ischemic penumbra (tissue at risk of infarction) and evaluate the risk of reperfusion injury in acute ischemic stroke patients. This research,...
This federal Project Grant award for $853,135 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research at Dignity Health's St. Joseph's Hospital and Medical Center in Phoenix, AZ to study the role of the complement C3A receptor in exacerbating brain injury and functional impairment following ischemic stroke. The research aims to...
This Project Grant award of $427,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop tools for studying proteome plasticity in brain endothelial cells. The goal is to elucidate the mechanisms by which changes in neuronal energy demands lead to reprogramming of signaling pathways that control brain blood flow, which is critical for...
This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the use of the adipokine adiponectin as a potential therapy to promote functional recovery after traumatic brain injury (TBI). The $571,404 award to the University of Pittsburgh will test the hypothesis that adiponectin receptor activation can mitigate...
This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...
This $624,583 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of Washington to identify potential therapeutic targets for preventing ischemic stroke. The project will leverage existing plasma samples, genomic data, and electronic medical records from the Heart and Vascular Health Study to evaluate...
The University of Rhode Island Research Office received a $413,729 Project Grant award on September 22, 2023 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to investigate the molecular links between stroke, the actin cytoskeleton, and Alzheimer's disease pathogenesis. The proposed work will use induced...