This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,359.00 to The Washington University in St. Louis to investigate the role of the MERTK receptor in cognitive and behavioral deficits associated with congenital Zika virus infection. The research aims to understand how increased MERTK signaling during Zika virus...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $544,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Texas Biomedical Research Institute to characterize a novel mouse model for studying the neurological impacts of Chikungunya virus infection. The research aims to determine the mechanisms by which Chikungunya virus infects the brain and evaluate whether the mouse model develops the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $512,056 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Rector & Visitors of the University of Virginia (UVA). The project, titled "CASPASE-8 MEDIATED CONTROL OF CNS INFECTION", will explore how specific cell types in the central nervous system utilize the cell death pathway activated by caspase-8 to control...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,613,015.00 in funding to the University of Washington to study the impact of maternal Zika virus infection on fetal immune response and brain development. The key objectives are to: 1) Define the effects of maternal viral infections and inflammation on the development of fetal innate and adaptive immunity in the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $500,000 in funding to Up Oncolytics, Inc. to validate a novel treatment for glioblastoma (GBM) using oncolytic Zika virus. The awardee is conducting IND-enabling experiments to advance this promising oncolytic virus therapy, which has demonstrated substantial...
The University of Rhode Island Research Office received a $413,729 Project Grant award on September 22, 2023 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to investigate the molecular links between stroke, the actin cytoskeleton, and Alzheimer's disease pathogenesis. The proposed work will use induced...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Brandeis University a $846,469 project grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to elucidate how the ESCRT (Endosomal Sorting Complex Required for Transport) machinery is regulated and deployed in neurons. The research aims to develop new visualization and manipulation tools to study ESCRT dynamics in Drosophila neurons, with the goal of providing mechanistic...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded a 3-year, $419,038 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of North Dakota to develop a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging of neural activity and astrocyte function in freely behaving mice. The key technical objectives are to:...
This federal Project Grant award, R21NS137258, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $235,500.00 award supports research at Rutgers, The State University to investigate the role of the p75 neurotrophin receptor (p75NTR) in regulating oligodendrocyte progenitor development and maturation in the subventricular zone of postnatal rats. The...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $628,133 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Rutgers, The State University, to conduct research on "Metabolic Mechanisms of Recovery in Mild TBI". The research aims to determine if activation of the CYPIN protein can be targeted after mild traumatic brain injury (TBI) to promote functional recovery in mice. The project will...