Project Grant R21MH144615
- The National Institute of Mental Health awarded the University of Pittsburgh $190,188 on June 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural substrates of perseverative thought disengagement and reward learning in early adolescence, with emphasis on the role of puberty in internalizing symptom development among girls. The project characterizes neural correlates of two constructs impacted by developing cognitive-affective brain networks:...
- The National Institute of Mental Health awarded the University of Pittsburgh $381,463 on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive responses to social threat and their links to social connectedness and suicidality in adolescent girls. The research employs multivariate electroencephalogram (EEG) decoding to assess neural representation of social threat information in working memory, ecological momentary assessment (EMA) to...
- The National Institute of Mental Health awarded the University of Pittsburgh $378,984 on March 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to test an integrative neurobiological model linking peripheral inflammatory markers to dysfunction in reward-related corticostriatal circuitry and adolescent suicidal ideation. The project, designated K23MH138759, will enroll 90 adolescents with unipolar depressive disorders enriched with those with a history of suicidal...
- The National Institute of Mental Health awarded the University of Pittsburgh $437,250 on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a longitudinal feasibility study examining the association between childhood gender nonconformity and early indicators of risk for suicidal behavior among children ages 7–10. The study collects data on psychosocial stressors, biological dysregulation in the hypothalamic-pituitary-adrenal axis and inflammatory pathways,...
- The National Institute of Mental Health awarded the University of Pittsburgh $149,190 under the Mental Health Research Grants program (CFDA 93.242) on August 18, 2026 to examine pathways to suicidality through negative urgency, neural threat processing, and daily social rejection in young adults. The research utilizes data from an ongoing R01 grant including six months of ecological momentary assessment, a personalized peer social feedback fMRI task, and self-report questionnaires from 150 young...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded the University of Pittsburgh $705,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate spatially-organized prefrontal circuits regulating fear expression and discrimination. The research examines how the rostral and caudal prelimbic cortex of the mouse brain differentially regulate fear responses to threats versus non-threats. The work addresses the pathogenesis of anxiety and trauma-related...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- The National Institute of Mental Health awarded the University of Pittsburgh $128,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH146391) to investigate how environmental enrichment during mid-adolescence fosters cortical plasticity and psychiatric resilience. The project tests the hypothesis that a critical period of heightened association cortex plasticity exists during mid-adolescence when environmental enrichment—encompassing physical,...
- The National Institute of Mental Health awarded the University of Pittsburgh $437,250 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate parvalbumin interneuron diversity and plasticity in primary visual and prefrontal cortical areas. The award funds a two-year exploratory research project running through March 31, 2028, conducted in Pittsburgh, Pennsylvania. The research uses patch-seq methodology to integrate single-cell RNA sequencing,...
The National Institute of Mental Health awarded the University of Pittsburgh $458,433 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop, refine, and validate a developmentally-tailored and ecologically-valid adolescent emotional faces stimulus set and examine the extent to which adolescents' socioaffective processing of these stimuli predicts unique variance in symptoms of anxiety, depression, suicidal ideation, and lifetime history of suicidal thoughts and behaviors. The project addresses a gap in available research stimuli, most of which depict adult faces and were designed for adult research populations. The new stimulus set will reflect adolescents' salient social context—specifically peer faces—to enable researchers to test adolescent-specific socioaffective mechanisms of psychiatric risk during a neurodevelopmental period marked by escalating depression, anxiety, and suicidal ideation. Development and refinement will incorporate input from a youth advisory board and a scientist stakeholder advisory board. Work is performed in Pittsburgh, Pennsylvania. The period of performance runs from September 1, 2026, through August 31, 2028. The award is structured as a Project Grant, an assistance type used for investigator-initiated research proposals evaluated on scientific and technical merit by peer review and the National Advisory Mental Health Council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.4k | 9/3/26 |