Project Grant K99MH146391
- The National Institute of Mental Health awarded the University of Pittsburgh $190,188 on June 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural substrates of perseverative thought disengagement and reward learning in early adolescence, with emphasis on the role of puberty in internalizing symptom development among girls. The project characterizes neural correlates of two constructs impacted by developing cognitive-affective brain networks:...
- The National Institute of Mental Health awarded the University of Pittsburgh $458,433 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop, refine, and validate a developmentally-tailored and ecologically-valid adolescent emotional faces stimulus set and examine the extent to which adolescents' socioaffective processing of these stimuli predicts unique variance in symptoms of anxiety, depression, suicidal ideation, and lifetime history of suicidal...
- The National Institute of Mental Health awarded the University of Pittsburgh $381,463 on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive responses to social threat and their links to social connectedness and suicidality in adolescent girls. The research employs multivariate electroencephalogram (EEG) decoding to assess neural representation of social threat information in working memory, ecological momentary assessment (EMA) to...
- The National Institute of Mental Health awarded the University of Pittsburgh $751,430 on August 4, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a multi-omic atlas of dendritic spine morphometry across postnatal development in neurotypical and autism spectrum disorder subjects. The research interrogates trajectories of synaptic protein network features—protein expression, synaptosome levels, and phosphorylation—in the prefrontal cortex and primary visual...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded the University of Pittsburgh $437,250 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate parvalbumin interneuron diversity and plasticity in primary visual and prefrontal cortical areas. The award funds a two-year exploratory research project running through March 31, 2028, conducted in Pittsburgh, Pennsylvania. The research uses patch-seq methodology to integrate single-cell RNA sequencing,...
- The National Institute of Mental Health awarded the University of Pittsburgh $158,960 on January 21, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate inhibitory control of dendritic spikes in hippocampal CA1 pyramidal neurons. The project will use optogenetics, two-photon calcium imaging, and voltage imaging to explore how dendrite-targeting somatostatin interneurons regulate dendritic spike dynamics, specifically examining how synaptic inhibition modifies...
- The National Institute of Mental Health awarded the University of Pittsburgh $378,984 on March 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to test an integrative neurobiological model linking peripheral inflammatory markers to dysfunction in reward-related corticostriatal circuitry and adolescent suicidal ideation. The project, designated K23MH138759, will enroll 90 adolescents with unipolar depressive disorders enriched with those with a history of suicidal...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $200,538 on December 14, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate functional cortical development and its relationship to transdiagnostic psychopathology risk. The recipient will map the functional organization of the cortex across development using a normative modeling framework applied to four large-scale developmental datasets: the Philadelphia...
- The National Institute of Mental Health awarded The Trustees of the University of Pennsylvania $110,228 under the Mental Health Research Grants program (CFDA 93.242) on November 4, 2026, to map person-specific and spatially precise white matter development to transdiagnostic psychopathology and polygenic risk in adolescents. The research characterizes within-individual, along-tract white matter development in relation to transdiagnostic psychiatric symptoms and evaluates whether associations are...
The National Institute of Mental Health awarded the University of Pittsburgh $128,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH146391) to investigate how environmental enrichment during mid-adolescence fosters cortical plasticity and psychiatric resilience. The project tests the hypothesis that a critical period of heightened association cortex plasticity exists during mid-adolescence when environmental enrichment—encompassing physical, cognitive, and social stimulation—maximally promotes cognitive health and resilience to psychiatric illness. The research leverages longitudinal data from the Adolescent Brain Cognitive Development Study (ABCD), a nationwide cohort of 11,878 youth, with MRI, cognitive, clinical, and environmental assessments collected at ages 9–10, 11–12, 13–14, 15–16, and 17–18. Aim 1 applies deep phenotyping of youths' physical, cognitive, and social environments to derive an individualized enrichment index and identify the developmental window when enrichment most substantially impacts complex cognition. Aim 2 characterizes the neurobiological mechanisms underlying plasticity-related outcomes across the adolescent lifespan. Performance of performance is Pittsburgh, Pennsylvania 15213. The project period runs through August 31, 2028. The award is structured as a K99 Pathway to Independence Award, which provides up to two years of support without renewal eligibility.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.2k | 8/31/26 |