Project Grant R21MH141559
- This federal Project Grant award of $422,280, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify and interrogate novel intracellular proteins that underlie the distinct nanoscopic architecture of the neurexin-1 and neurexin-3 proteins. The research aims to determine how the intrinsically monomeric neurexins are organized into discrete and homogeneous nanoclusters, which is a fundamentally...
- The National Institute of Mental Health (NIMH) awarded a $1,737,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Max Planck Florida Corp, doing business as Max Planck Florida Institute For Neuroscience. The 3-year project, starting September 1, 2024, aims to systematically investigate the synaptic energy logistics that enable the brain to process and store information. Specifically, the research will discover novel regulators that dictate the flexibility of...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $121,933 to the University of California, San Diego (UCSD) to conduct research on the functional organization of synaptic inputs along the dendrites of layer 2/3 pyramidal neurons in behaving animals. The research aims to characterize how synapses from different input regions are spatially and functionally organized, determine the...
- This federal Project Grant award of $136,050.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate how a specific protein, BTBD11, regulates the function and composition of glutamatergic synapses in interneurons. The research aims to elucidate the role of BTBD11 and liquid-liquid phase separation in maintaining the unique properties of glutamatergic synapses in interneurons, which are...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $706,404 to Thomas Jefferson University to conduct research on the pathophysiological roles of protein-protein interactions at excitatory synapses and their modifications in schizophrenia. The research aims to determine how defects in protein-protein interactions drive NMDA receptor hypofunction, a key aspect of the synaptic pathology in...
- This federal Project Grant award of $692,043 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of presynaptic homeostatic plasticity in mental health disorders such as autism and intellectual disability. The award recipient, The Regents of the University of California, San Francisco (UCSF), will conduct research to elucidate the molecular mechanisms underlying homeostatic plasticity and...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the agency's Mental Health Research Grants program (CFDA 93.242), provides $162,486 to The Johns Hopkins University to study single neuron computations within brain-wide circuits. The research aims to characterize the spatiotemporal relationships between synaptic input patterns and action potentials, investigate how inputs change when the brain drives activity in specific neurons, and determine whether...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $551,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of California, Los Angeles (UCLA) to support research focused on understanding the molecular mechanisms underlying the formation of synaptic connections between neurons in the brain. The key research aims are to uncover the molecular basis of synaptic specificity in the...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $429,000.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to develop and apply tools for manipulating biomolecular condensates in neurons in order to modulate the properties of the postsynaptic density and assess the functional consequences on synaptic structure and plasticity. The two-year project...
- This $108,486 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of Florida focused on exploring the role of the nonmuscle myosin IIB (NMIIB) motor protein in regulating synaptic actin dynamics. The research aims to elucidate how NMIIB contributes to structural plasticity in dendritic spines, which is...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $427,625 to support research focused on understanding the molecular organization and functional impact of synaptic vesicle docking sites within neuronal synapses. The award aims to elucidate how the proteins of the presynaptic active zone and postsynaptic density assemble into the functional complexes that mediate synaptic transmission, a critical area for understanding mechanisms underlying neuropsychiatric disorders. The research will leverage advanced fluorescence microscopy techniques to identify and characterize the transsynaptic molecular context of docked synaptic vesicles, providing insights into the relationship between structural organization and the strength, frequency-dependence, and regulation of neurotransmission. The project will be conducted by the University of Maryland, Baltimore over the period from September 11, 2025 to September 10, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 9/11/25 |