The federal Project Grant award R21MH140328 was provided by the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The $422,280 award, effective from April 1, 2025 to March 31, 2027, supports research to identify and interrogate novel intracellular proteins that underlie the distinct nanoscopic architecture of the presynaptic proteins...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research at the University of Colorado-Denver to investigate the mechanisms by which inhibitory GABAergic synapses heterosynaptically regulate excitatory glutamatergic synapses during brain development and plasticity. The $429,000 grant, awarded on August 1, 2024, will support the use of advanced optical techniques to address two key questions:...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $466,757 to the University of Texas at Austin to conduct research on the synaptic plasticity mechanisms that protect and refine local neural circuits in the brain. The goal is to understand how synapse structure supports learning and memory, with a focus on dendritic spines and the active zones where neurotransmitter release occurs. The...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund research at the University of Colorado-Denver to investigate the role of synaptic adhesion molecules in guiding myelination of specific axons. The $429,000 grant, awarded from June 2025 to May 2027, will support the development of novel tools to visualize gene expression and protein localization related to axon-myelin interactions in living...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $692,043 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the role of presynaptic homeostatic plasticity in mental health disorders, including autism and intellectual disability. The project aims to elucidate the molecular mechanisms by which homeostatic plasticity, a process that stabilizes neural...
The National Institute of Mental Health (NIMH) awarded a $1,737,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Max Planck Florida Corp, doing business as Max Planck Florida Institute For Neuroscience. The 3-year project, starting September 1, 2024, aims to systematically investigate the synaptic energy logistics that enable the brain to process and store information. Specifically, the research will discover novel regulators that dictate the flexibility of...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $121,933 to the University of California, San Diego (UC San Diego) to investigate the compartment-specific functional organization of synaptic inputs along the dendrites of layer 2/3 pyramidal neurons in behaving animals and the mechanisms that shape this organization during learning. The research aims to characterize how synapses from different...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This Project Grant award of $185,165.00 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research at Colorado State University (CSU) to investigate how the microRNA miR-137 affects both metabolic and neuronal function. The overarching goal is to understand how miR-137-driven metabolic dysfunction may contribute to the development and progression of neuropsychiatric disorders like schizophrenia and bipolar disorder. The...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $457,026 to Magnify Biosciences Inc. from August 1, 2024 to July 31, 2026. The goal of this project is to develop a prototype of the "Multiplex Magnify" sample preparation kits as a universal tool for synapse typing and advanced 3D brain imaging in neuroscience research. The key products and services to be delivered include:...