Project Grant R21MH141461
- This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of group III metabotropic glutamate receptors (mGlu4/7/8) in modulating glutamatergic signaling and their potential as targets for treating schizophrenia. The $217,818 award to Vanderbilt University, effective from September 9, 2025 to September 8, 2027, will fund studies to use pharmacological and...
- This Project Grant award of $396,250 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at Vanderbilt University to investigate the regulation of metabotropic glutamate receptor (mGluR) activity by protein-protein interactions. The research aims to: 1) test a suite of agonists, positive allosteric modulators (PAMs), and negative allosteric modulators (NAMs) for activity at mGluR7 with and without the protein...
- This federal Project Grant award of $237,399 from the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) supports research by Vanderbilt University to investigate the role of the metabotropic glutamate receptor 7 (mGluR7, GRM7) as a potential genetic modifier of cognitive deficits in neurofibromatosis type 1 (NF1). The research aims to understand how variations in the GRM7 gene may impact learning...
- This Project Grant award of $158,500.00 from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) supports research by Vanderbilt University to investigate the role of the metabotropic glutamate receptor 7 in learning processes associated with neurofibromatosis type 1 (NF1). The research aims to advance the understanding of the neurological mechanisms underlying NF1 and identify potential therapeutic approaches. The award period runs from June 1, 2025 to...
- This federal Project Grant award of $422,280, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify and interrogate novel intracellular proteins that underlie the distinct nanoscopic architecture of the neurexin-1 and neurexin-3 proteins. The research aims to determine how the intrinsically monomeric neurexins are organized into discrete and homogeneous nanoclusters, which is a fundamentally...
- This federal Project Grant award of $136,050.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate how a specific protein, BTBD11, regulates the function and composition of glutamatergic synapses in interneurons. The research aims to elucidate the role of BTBD11 and liquid-liquid phase separation in maintaining the unique properties of glutamatergic synapses in interneurons, which are...
- The Department of Health and Human Services, National Institutes of Health (NIH) awarded a $1,349,865 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Vanderbilt University. The grant, titled "Illuminating the Molecular Logic of Mammalian Synaptic Circuit Assembly," will fund a multidisciplinary research project to investigate the biological functions and signaling mechanisms of Adhesion G Protein-Coupled Receptors (AGPCRs) and their role in the assembly of...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $600,000 to Vanderbilt University Medical Center (VUMC) to add ultra-high performance magnetic field gradients and amplifiers to a 3 Tesla magnetic resonance imaging (MRI) and spectroscopy research scanner. This new equipment will dramatically improve the quality of neuroimaging data, enabling enhanced diffusion tractography, functional MRI, and...
- This federal Project Grant award of $774,632 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to understand how changes in dopamine signaling impact neural circuits and contribute to symptoms like impaired cognition and perception in dopamine-associated neuropsychiatric diseases. The key objectives are to use in vivo imaging to determine how selectively activating dopamine neurons in the...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $2,565,783 to Oregon Health & Science University (OHSU) from September 1, 2023 to August 31, 2026 to develop novel genetically encoded sensors and actuators for monitoring and manipulating neuromodulatory signaling activities in the brain at the cellular and circuit levels. The project aims to enable large-scale in vivo...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $435,875 to Vanderbilt University to identify the molecular signatures of metabotropic glutamate (mGlu) receptor heterodimers. The project aims to investigate the role of mGlu7 receptor heterodimerization and its impact on receptor pharmacology, with a focus on understanding its implications for neurodevelopmental disorders like Rett syndrome. The research will be conducted over a 2-year period from September 1, 2025 to August 31, 2027 at Vanderbilt University in Nashville, Tennessee. The findings from this grant-funded research are expected to provide insights that could lead to more targeted therapeutic approaches for mental health conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 9/1/25 |