This $251,250 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research investigating the impact of maternal antibodies to the CASPR2 protein on the development of parvalbumin interneurons and their role in autism spectrum disorder (ASD). The research aims to determine whether in-utero exposure to anti-CASPR2 antibodies results in sex-specific epigenetic effects that disrupt the normal maturation of...
This $680,092 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to uncover sex-specific differences in Ash1L gene-related neuropsychiatric disorders at Brown University. The research aims to 1) define the clinical diversity and severity of neurological presentations associated with Ash1L mutations in males versus females, and 2) characterize the sex-specific cellular and molecular phenotypes...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The $911,929 grant will fund a 5-year research project to combine in vivo genetic screening with spatial mapping of brain cell types to study the mechanisms by which genetic variants associated with autism spectrum disorder (ASD) and neurodevelopmental delay lead to these conditions. The project will adapt...
This $534,004 Project Grant awarded by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to Rutgers, The State University will fund research to investigate the role of corticolimbic brain circuits in regulating maternal behavior, threat responses, and stress responses during the postpartum period. The 5-year research project aims to: 1) identify specific cell populations within corticolimbic areas responsible for...
This $1,505,818 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research into understanding how the gene Neurexin 1 impacts social behavior and flexibility through its influence on the prefrontal cortex-amygdala neural circuit. The grant, awarded to Rosalind Franklin University of Medicine & Science, will fund a 5-year study using rodent models to investigate how Neurexin 1 disruption affects...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,049,254 to Cold Spring Harbor Laboratory to investigate the role of transient neuronal connectivity in the development and maturation of cortical circuits, and its implications for the treatment of Fragile X Syndrome. The research aims to elucidate the mechanisms by which sensory and neuromodulatory inputs establish transient connections with...
The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Rutgers, The State University of New Jersey, to investigate how the cytokine interleukin-6 (IL-6) affects the proliferation, specification and gene expression of human and mouse secondary neural progenitor cells. The goal is to establish IL-6 as a key target for intervention to prevent neurodevelopmental disorders like...
This Project Grant award of $142,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to study sex differences in the effects of neonatal pain and stress on emotional and sensory dysfunction in male and female rats. The key research objectives are to: Examine changes in neuropeptide gene expression and cellular phenotypes in the amygdala and hypothalamus between male and female rats exposed to...
This Project Grant award, totaling $388,800, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The purpose of the grant is to evaluate cognitive systems and psychopathology in autistic individuals who carry rare genetic variants associated with both autism spectrum disorder (ASD) and schizophrenia (SCZ). The study, led by The Trustees of Columbia University in the City of New York, will remotely assess cognition and...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $194,375 to support research on the impact of midbody remnant (MBR)-mediated genetic information transfer on cortical development in the context of an autism spectrum disorder (ASD)-linked PTEN mutation. The key objectives are to: 1) Determine how the PTEN(+/-) mutation alters the molecular composition of MBRs during neural differentiation of...