Project Grant R21MH136532
- Summary: GSM-779690 Safety Demonstration Studies The University of California, San Diego received a $3.225 million Cooperative Agreement from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 15, 2025, with a completion date of July 31, 2027. The award funds in vitro pharmacology, chronic toxicology, and embryo-fetal development studies to demonstrate the safety profile of GSM-779690, a small-molecule gamma-secretase modulator being developed as a...
- Grant Award Summary Alphamemory, LLC received a Phase I Small Business Technology Transfer (STTR) award of $504,248 from the National Institute on Aging under the Aging Research program (CFDA 93.866) on September 20, 2025. The award supports drug discovery research targeting the transmembrane domain of the amyloid precursor protein (APP) as an alternative approach to reduce amyloid production in Alzheimer's disease. This research strategy addresses limitations of previous gamma-secretase...
- This federal Project Grant award of $647,833 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research conducted by Northwestern University to investigate cellular mechanisms underlying excitation/inhibition imbalance in the medial prefrontal cortex as a convergent pathogenic mechanism across genetic mouse models relevant to schizophrenia. The key research objectives are to: 1) determine the reversal potential of the...
- This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $460,855 to New York University School of Medicine to investigate the cellular and circuit mechanisms by which acetylcholine (ACh) promotes associative learning in the primary somatosensory cortex. The key objectives are to: 1) use fluorescent ACh sensors and chemogenetic techniques to study the magnitude and time course of ACh release during different phases of an...
- Summary: Neurophysiological Correlates of Cognition Over Multi-Day Timescales in Epilepsy The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital $234,630 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a five-year prospective research study examining the neurophysiological basis of cognitive impairment in temporal lobe epilepsy (TLE). The research...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $429,000.00 in funding to Thomas Jefferson University to conduct research on cell-type specific analysis of Src kinase-NMDA receptor complexes in schizophrenia. The goal of this 2-year project is to determine how Src kinase-mediated NMDA receptor signaling alterations are distinctly manifested in pyramidal neurons versus interneurons in the...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $388,158.00 to the University of California, Los Angeles (UCLA) to engineer a highly active and selective gamma-Aminobutyric Acid (GABA) oxidase enzyme. The goal is to develop a high-performance, implantable, electroenzymatic GABA microsensor that can monitor GABA transients in the...
- Federal Project Grant Award Summary Psychogenics Inc. received a $495,699 project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 20, 2025, with completion targeted for September 19, 2027. The project focuses on the development and preclinical evaluation of PGI-5128, a novel drug candidate designed to treat agitation and aggression in Alzheimer's disease patients. Phase I deliverables include efficacy studies of PGI-5128 in...
- Federal Cooperative Agreement Summary Weill Medical College of Cornell University received a $3.25 million Cooperative Agreement from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded April 1, 2026, with completion targeted for March 31, 2028. The agreement funds a Phase 1A clinical safety and dose-ranging trial of AAVRH.10HAPOE2CH, a novel gene therapy vector designed to treat Apolipoprotein E4 (APOE4) homozygous Alzheimer's disease. The therapeutic...
- This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...
A PRECLINICAL THERAPEUTIC PLATFORM TO DEVELOP GABAA ALPHA5 RECEPTOR POSITIVE ALLOSTERIC MODULATORS TO IMPROVE COGNITIVE FUNCTION IN SCHIZOPHRENIA - A PRECLINICAL THERAPEUTIC PLATFORM TO DEVELOP GABAA A5 RECEPTOR POSITIVE ALLOSTERIC MODULATORS TO IMPROVE COGNITIVE FUNCTION IN SCHIZOPHRENIA. COGNITIVE DYSFUNCTION IN NEUROPSYCHIATRIC DISORDERS SUCH AS SCHIZOPHRENIA PREDICTS LONG-TERM DISABILITY AND POOR PATIENT OUTCOME AND IS NOT EFFECTIVELY TREATED WITH EXISTING STANDARD-OF-CARE MEDICATIONS. CONVERGING EVIDENCE INDICATES THAT A PRIMARY SOURCE OF THIS COGNITIVE IMPAIRMENT IS AN IMBALANCE IN EXCITATORY/INHIBITORY (E/I) NEURAL RESPONSES IN CRITICAL CIRCUITRY FOR EPISODIC MEMORY. IN THE MEDIAL TEMPORAL LOBE, WEAKENED INHIBITION INDUCES AN ABERRANT CONDITION OF INCREASED EXCITATION IN THE HIPPOCAMPUS OF INDIVIDUALS WITH SCHIZOPHRENIA. THE AIM OF THIS PROPOSAL IS TO DEVELOP NOVEL THERAPEUTICS TO REMEDIATE E/I IMBALANCES TO IMPROVE COGNITIVE FUNCTION. USING A PRECLINICAL PLATFORM FOR DRUG DEVELOPMENT, THE PROPOSED RESEARCH IS FOCUSED ON GABAA A5 RECEPTOR POSITIVE ALLOSTERIC MODULATION (PAM) FOR THE TREATMENT OF NEUROPSYCHIATRIC CONDITIONS CHARACTERIZED BY HEIGHTENED EXCITATION IN THE HIPPOCAMPUS. THE HIGH EXPRESSION OF A5-CONTAINING GABAA RECEPTORS IN THE HIPPOCAMPUS, WHICH MEDIATE TONIC INHIBITION, COULD BE IDEAL FOR CONTROLLING EXCITATION IN THIS CIRCUITRY. WE WILL USE A SERIES OF SMALL MOLECULES WITH HIGH POTENCY AND SELECTIVITY FOR GABAA A5 RECEPTORS AND PAM ACTIVITY AT THE A5 SUBUNIT THAT HAVE MET PRECLINICAL IN VITRO AND IN VIVO DRUG DISCOVERY CRITERIA WITH POTENTIAL FOR TRANSLATIONAL DEVELOPMENT AS THERAPEUTIC AGENTS. THE CURRENT PROPOSED STUDIES WILL ADVANCE THIS DRUG DEVELOPMENT PLATFORM TO TEST THE EFFICACY OF TWO GABAA A5 RECEPTOR PAMS TO IMPROVE HIPPOCAMPAL-DEPENDENT COGNITION IN A PREPARATION OF HIPPOCAMPAL OVERACTIVITY IN RODENTS. THE STUDIES WILL ALSO ASSESS EFFICACY BY USING FIBER PHOTOMETRY TO MONITOR NEURAL HYPEREXCITATION IN THE HIPPOCAMPAL FORMATION DURING IN VIVO TESTING. TOGETHER, THESE STUDIES ESTABLISH A FOUNDATION FOR A PRECLINICAL SMALL MOLECULE DRUG DEVELOPMENT PROGRAM TO REMEDIATE E/I IMBALANCES UNDERLYING COGNITIVE DYSFUNCTION IN NEUROPSYCHIATRY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/13/26 | ||
| Not listed | $204.7k | 8/17/25 | ||
| Not listed | $245.6k | 7/29/24 |