This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to engineer a highly selective and active G-aminobutyric acid (GABA) oxidase enzyme. The $388,158 grant, awarded on July 15, 2024, with an ultimate completion date of June 30, 2026, will fund the development of a high-performance, implantable, electroenzymatic GABA microsensor. This sensor technology will enable real-time monitoring of GABA, the brain's primary inhibitory neurotransmitter, at the cellular level. The project will leverage the University of California, Los Angeles' (UCLA) expertise in protein engineering, neuroscience, and implantable microsensor construction to create a tool that will help illuminate the function of critical neural circuitry. The goal is to address the current lack of technology to monitor GABA transients, which are associated with neurological disorders affecting approximately 25 million people in the US.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $388.2k | 7/5/24 |