This $1,650,642 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will fund research to determine the circuit and behavioral roles of parvalbumin-expressing GABAergic neurons in the basal forebrain (BF-PV neurons) and their support of sustained attention. The award recipient, The Washington University in St. Louis, will use quantitative behavior, cell-type-specific recordings and manipulations, viral tracing, and computational modeling to map BF-PV cortical projections, investigate their role in cortical gain control, and assess how BF-PV neuron dynamics predict and influence momentary attention levels during sustained attention tasks. This work aims to elucidate how this understudied, long-range BF-PV neuron pathway supports sustained attention, which could provide insights into new therapeutic targets for attention disorders and basal forebrain-related dementias.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $485.7k | 5/6/25 | ||
| Not listed | $582.5k | 8/29/24 | ||
| Not listed | $582.5k | 8/29/24 |