Project Grant R21HL179596
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $639,151 to Augusta University Research Institute, Inc. to investigate sex differences in the gut microbiome, immune system, and their role in salt-sensitive hypertension and kidney disease. The research will be conducted using Dahl salt-sensitive rat models and human samples from an opposite-sex twin cohort. The key...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $616,521 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Baylor College of Medicine to study the role of bacterial extracellular vesicles (EVs) in the gut-brain-hypertension axis. The project aims to: 1) identify the specific bacteria producing EVs that contribute to hypertension, 2) examine the effects of bacterial EVs on gut epithelial inflammation, and 3) define the impact of bacterial EVs on neuroinflammation...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is supporting research to investigate how gut microbe-derived lipids, specifically N-acyl amides, can signal through the host receptor GPR119 to impact inflammatory and metabolic pathways related to cardiometabolic diseases like obesity and atherosclerosis. The $743,302 award to the Cleveland Clinic Lerner College of Medicine of Case Western...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $720,399 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Colorado-Denver. The 5-year project, running from Sep 1, 2025 to May 31, 2030, will investigate the associations between maternal microbiomes, metabolomes, and cardiovascular health outcomes in a racially and ethnically diverse pregnancy cohort. Key objectives are to characterize...
- This Project Grant award, valued at $249,000.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant supports a research project at the University of Alabama at Birmingham (UAB) titled "Early Life Stress and Cardiovascular Disease Risk: Identifying the Role of Microbial Metabolites." The project aims to investigate how early life stress affects the gut microbiome and related...
- The National Heart, Lung, and Blood Institute (NHLBI), a part of the National Institutes of Health, awarded a $163,923 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Duke University's Office of Research Administration Division. This 5-year, mentored patient-oriented research career development award (K23) will support Dr. Sarah Heston's research on the role of the gut microbiome in the development of acute gastrointestinal graft-versus-host disease (GI-GVHD) in...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $717,236 to The University of Iowa to study the role of neuronal primary cilia in hypertension, autonomic dysfunction, and body fluid imbalance. The goal is to evaluate how conditional ablation of cilia in the supraoptic nucleus affects blood pressure, drinking, urine volume, sodium concentration, plasma osmolality, regional sympathetic...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $239,800 to Louisiana State University Health Sciences Center-Shreveport to investigate the role of arterial baroreceptors in the development of hypertension. The research aims to develop novel methods to selectively target these sensory neurons and understand how chronic elevations in blood pressure disrupt their function, potentially contributing to...
- This Project Grant award, totaling $786,060.00, was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to investigate how hypertension induces "trained immunity" in myeloid cells, which may drive the development of atherosclerosis even after lowering cholesterol and blood pressure. Key research activities include: Transplanting hematopoietic stem and progenitor cells from hypertensive mice into...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $399,174 to the University of Toledo to develop and utilize an innovative microfluidic tri-culture model. This model enables side-by-side co-culturing of anaerobic gut bacteria, colonic epithelial cells, and vagal sensory neurons to study the mechanistic pathways linking gut dysbiosis, colonic serotonin signaling, and vagal afferent 5-HT3 receptor activation in the context of hypertension. The goal is to conduct semi-high throughput screening to elucidate how specific gut bacteria, such as Akkermansia muciniphila, may influence colonic serotonin production and vagal neuronal signaling to regulate blood pressure. This innovative approach aims to provide new insights into the microbiota-gut-brain axis that underpins hypertension, with potential to identify novel therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.2k | 8/18/25 |