This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on investigating the role of conjugated bile acids as potential antihypertensive metabolites. The $768,896 grant will be used to address two key questions: 1) why are conjugated bile acids depleted in hypertension, and 2) what is the mechanism by which conjugated bile acids, particularly taurocholic acid, provide protection against...
This Project Grant award in the amount of $717,236 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), with a performance period from December 15, 2024 to November 30, 2028. The grant supports research focused on understanding the role of neuronal primary cilia in hypertension, autonomic dysfunction, and body fluid imbalance. The research aims to evaluate how conditional ablation of cilia in the...
This $743,302 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI)'s Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate how gut microbiome-derived lipids, specifically N-acyl amides, can signal through the host receptor GPR119 to regulate inflammation and metabolism in cardiometabolic diseases. The principal investigator will leverage innovative methods to increase circulating levels of these bacterial lipids and evaluate their...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $639,151 to Augusta University Research Institute, Inc. to investigate sex differences in the gut microbiome, immune system, and their role in salt-sensitive hypertension and kidney disease. The research will be conducted using Dahl salt-sensitive rat models and human samples from an opposite-sex twin cohort. The key...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $705,279 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Trustees of Boston University to conduct research on the impact of environmental pollutants on the cardiovascular system. The 4-year project, starting on January 1, 2025, will characterize the effects of persistent organic pollutants and environmental toxicants on vascular function, angiogenesis, and adipocyte biology. The research involves...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,218,392.00 to Yale University to conduct research on the role of the lymphatic system in the pathogenesis of cerebral small vessel disease (CSVD) associated with chronic hypertension. The research aims to characterize the coupling between the glymphatic and lymphatic systems, determine how lymphatic drainage deficits contribute to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $528,179 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to the University of Miami to investigate novel strategies for improving neovascularization and limb perfusion in peripheral arterial disease and critical limb ischemia. The research aims to determine if extracellular vesicles mediate a systemic effect that reprograms bone marrow-derived monocytes, and whether modulating the DHCR24 enzyme in myeloid cells can...
This $250,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research at Colorado State University to investigate the role of maternal gut microbiome and inflammation in preeclampsia and subsequent cardiometabolic disease in offspring. The key research aims are to: 1) Determine if the maternal gut microbiome contributes to pro- or anti-inflammatory short-chain fatty acid signaling at the...
This federal Project Grant award, totaling $249,000.00, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports the development of methodologies to reveal the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The project aims to develop a strain-resolved computational pipeline for reduced metagenomic sequencing to profile the blood microbiome, and a deep learning framework to...
The University of Florida was awarded a $1,410,766 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837). The project, titled "Analyzing Effectiveness of Ongoing Natural Experiments in Telehealth," aims to evaluate the utilization and impact of telehealth and home blood pressure monitoring strategies implemented by healthcare systems during the COVID-19 pandemic to manage uncontrolled...