Project Grant R00HL175100
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $717,236 to The University of Iowa to study the role of neuronal primary cilia in hypertension, autonomic dysfunction, and body fluid imbalance. The goal is to evaluate how conditional ablation of cilia in the supraoptic nucleus affects blood pressure, drinking, urine volume, sodium concentration, plasma osmolality, regional sympathetic...
- This $146,703 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the cellular and molecular mechanisms underlying respiratory control dysfunction in hypertension. The principal investigator will use electrophysiology and imaging approaches to study the role of the retrotrapezoid nucleus (RTN) in regulating the respiratory response to changes in CO2/H+ in spontaneously hypertensive rats. The...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $644,687 to the University of Missouri System to conduct research on a neural circuit in the brain that contributes to hypertension associated with obstructive sleep apnea. The research aims to determine how this "orexin-CRH-NTS" circuit facilitates the peripheral chemoreflex and leads to sympathoexcitation and hypertension,...
- The University of Alabama at Birmingham (UAB) received a $222,750 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to develop a clinical decision support questionnaire to identify barriers to blood pressure control. The project aims to address the high rates of uncontrolled hypertension in the U.S., which is a leading cause of morbidity, mortality, and substantial healthcare costs. The award, with a performance period from July...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,084,359 to Nusirt Sciences, Inc. to conduct clinical validation of the fixed combination drug product NS-0200 for the treatment of hypertension. The award will support research activities from September 15, 2025 through June 30, 2027 to evaluate the efficacy and safety of this novel hypertension treatment. Hypertension is a major global health issue, affecting...
- This $114,180 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to elucidate the role of renal afferent nerves in regulating blood pressure. The project aims to 1) trace the central terminations and regional specificity of renal afferents, and 2) identify how renal afferent input influences the activity of central autonomic...
- This $285,195 project grant was awarded on August 20, 2025 by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc. to support research on improving hypertension management through patient self-titration of antihypertensive medications. The project aims to adapt this intervention to the U.S. primary care context by assessing patient preferences, provider perspectives, and integration with electronic health records and...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- This Project Grant award of $249,000.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to investigate the calcium-dependent autoregulation of vasopressin neurons in a rodent model of heart failure. The key objectives are to test the hypothesis that impaired intracellular calcium signaling and somatodendritic release of vasopressin lead to the hyperexcitability and excess peripheral vasopressin...
- The National Heart, Lung, and Blood Institute (NHLBI), which is part of the National Institutes of Health (NIH), awarded a $688,525 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, San Diego (UCSD). The grant, titled "Blood Pressure Control Advancing Refugee Health Equity (BPCARE): An RCT of Adherence", aims to develop and test a behavioral intervention to improve antihypertensive medication adherence and blood pressure...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $239,800 to Louisiana State University Health Sciences Center-Shreveport to investigate the role of arterial baroreceptors in the development of hypertension. The research aims to develop novel methods to selectively target these sensory neurons and understand how chronic elevations in blood pressure disrupt their function, potentially contributing to drug-resistant hypertension. The 3-year project, starting September 1, 2025, will explore the hypothesis that arterial baroreceptors utilize a combination of ion channels to transduce mechanical stretch into blood pressure-regulating neural signals, and that this system becomes dysregulated in hypertension. The findings could elucidate neural mechanisms underlying hypertension and identify new therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $239.8k | 7/30/25 |