Project Grant R21HL179322
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $708,063 in funding to the University of Virginia for a research project titled "Post-Transcriptional Regulatory Networks in Chronic Obstructive Pulmonary Disease". The goal of the 5-year project is to generate RNA-binding protein (RBP) regulatory networks, identify COPD-specific changes, and characterize the functional consequences of the network changes....
- This Project Grant award of $800,679.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support the University of Virginia's research to interrogate the pathogenesis of chronic obstructive pulmonary disease (COPD) using metabolomics and genomics data. The objective is to expand the PredixCan method to incorporate metabolomics data, creating a new tool called MetaBoxCan, in order to extract more comprehensive mechanistic information from...
- This Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund the development of novel computational methods to investigate the role of DNA methylation in the progression of Chronic Obstructive Pulmonary Disease (COPD). The $1,470,578 award, spanning from January 1, 2025 to December 31, 2028, will enable researchers at the University of Florida to assemble and analyze multi-omic data from large COPD...
- This federal Project Grant award, totaling $765,612.15, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to conduct a molecular analysis of airway secretory cells in the context of Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of death in the U.S. and worldwide. The research, taking place at the Research Institute at Nationwide Children's Hospital in Columbus, Ohio,...
- This federal Project Grant award of $805,921 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to integrate multi-trait, multi-ancestry, and multi-omic data from massive global biobanks to decipher the genetic mechanisms underlying respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. The award, with a performance period from September 2025 to June 2030, will leverage data from over 2 million participants,...
- This Project Grant award of $762,867.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the cofilin-1 protein in regulating mitochondrial function and quality control in airway epithelial cells. The research, conducted by The Johns Hopkins University, seeks to understand how the loss of cofilin-1 impacts mitochondrial dynamics and mitophagy, and how these processes contribute to airway epithelial dysfunction in...
- This Project Grant award for $702,103 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to systematically define the signaling pathways by which the protein SFTA2 interacts with the receptor ADGRF5 to control pulmonary surfactant homeostasis. The awardee, National Jewish Health, a non-profit research center in Colorado, will use cell-based assays and mouse genetics to test the hypothesis that SFTA2 regulates alveolar surfactant...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $370,452 to The Johns Hopkins University to conduct research on the impact of financial toxicity on health outcomes for individuals with chronic obstructive pulmonary disease (COPD). The study will use quantitative and qualitative methods to evaluate the association between financial toxicity, disability, health-related quality of life, and medication adherence in...
- The federal Project Grant award of $760,374 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research by National Jewish Health to develop predictive molecular signatures for diagnosing sarcoidosis and identifying patients at risk of disease progression. The project will integrate single nucleotide polymorphisms, gene expression, and plasma metabolomics/lipidomics data using advanced machine learning to identify potential biomarkers....
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
This $234,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Thomas Jefferson University to characterize the expression pattern of circulating short non-coding RNAs (sncRNAs) as potential biomarkers for chronic obstructive pulmonary disease (COPD). The researchers will obtain plasma samples from the SPIROMICS study to quantify the levels of two specific sncRNAs, IMMR-Val and IMMR-His, that were previously found to be upregulated in COPD patients. This larger-scale study aims to gain a comprehensive understanding of how these novel immunoactive sncRNAs are associated with COPD pathogenesis, with the goal of developing them as early diagnostic biomarkers. The award period is from September 1, 2025 through August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $234.0k | 8/27/25 |