This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,549,670 to Brigham & Women's Hospital to study the clinical implications and proteomics of bronchiectasis progression in smokers.
The key objectives are to:
Validate the effectiveness of an artificial intelligence-based computed tomography (CT) imaging tool for detecting and tracking changes in bronchiectasis in...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a risk assessment tool to identify individuals with undiagnosed chronic obstructive pulmonary disease (COPD) by leveraging quantitative imaging data from lung cancer screening.
The $626,247 award, which runs from September 1, 2024 to July 31, 2028, will support the following activities: 1) using quantitative imaging analysis to...
This $827,682 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to characterize pulmonary perfusion and develop imaging approaches to guide treatment of Acute Respiratory Distress Syndrome (ARDS). The awardee, The General Hospital Corporation's Research Management Division (doing business as Massachusetts General Hospital), will leverage dynamic contrast-enhanced CT, dual energy CT,...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, will fund the development of an AI-assisted strategy for monitoring pulmonary congestion in acute heart failure patients in emergency settings.
The $608,944 award to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, aims to automate lung...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), CFDA 93.837 Cardiovascular Diseases Research program, will fund a research study to characterize and automate metrics of airway and chest wall deformation in chronic obstructive pulmonary disease (COPD) patients. The $116,625 award, effective September 1, 2024 through June 30, 2026, will leverage established datasets from the Multi-Ethnic Study of Atherosclerosis Lung (MESALUNG) and COPDGene studies...
This $604,115 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund an observational study by The General Hospital Corporation (Massachusetts General Hospital) to determine if advanced PET and MRI imaging technologies can predict which individuals with non-IPF interstitial lung disease are at highest risk of developing progressive pulmonary fibrosis (PPF). The research aims to enable early...
This Project Grant award of $2,102,163 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to implement an integrative genomic approach to identify genetically-driven pathways of chronic obstructive pulmonary disease (COPD). The primary awardee, Brigham & Women's Hospital, will use existing and generate new GWAS data, along with transcriptomics, proteomics, and newly collected lung/blood metabolomics data from 1,500 subjects, to determine...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), totaling $794,681, supports research to evaluate the impact of non-COPD medications on outcomes for patients with chronic obstructive pulmonary disease (COPD). The overarching goal is to develop a data infrastructure to robustly and validly assess the effects of non-COPD drugs on COPD outcomes, leveraging existing claims data and linking it to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $116,625 to The University of Iowa to characterize novel phenotypes related to osteoporosis and sarcopenia in chronic obstructive pulmonary disease (COPD). The project aims to develop automated chest CT-based measures of thoracic bone density, muscle mass, and lung diaphragmatic surface deformation, and build normative models of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $144,989 to The General Hospital Corporation Research Management Division, doing business as Massachusetts General Hospital (MGH), to develop deep generative models using CT images to predict the progression and treatment response of Acute Respiratory Distress Syndrome (ARDS).
The goal is to leverage artificial intelligence and deep...