Project Grant R21HD121004
Award Date 9/1/26
Completion Date 8/31/28
Dollars Obligated $453K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Columbus, OH 43210, USA
Similar Awards
- The National Institute of Child Health and Human Development awarded The Ohio State University $157,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.HDR) to evaluate the dynamics of developmental tube morphogenesis. The recipient will construct and validate a computational framework combining mathematical modeling and image-based analysis to investigate how mechanical forces and genetic regulation coordinate biological tube formation and...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded The Ohio State University $199,800 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support predoctoral training in neurotrauma research through the NEURO-RISE program. The award funds two years of interdisciplinary graduate training for predoctoral trainees selected from the Neuroscience, Psychology, or Health and Rehabilitation Science doctoral programs. The curriculum...
- The National Institute of Child Health and Human Development awarded The Ohio State University $177,769 on October 15, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of maternal stress and poly(I:C)-stimulated viral activation on placental immune dynamics and offspring neurobehavioral development. The research applies an established prenatal stress and viral-mimetic exposure model to transgenic mice expressing tdTomato in...
- The National Institute of Child Health and Human Development awarded The Ohio State University $426,914 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate microRNA mechanisms in Angelman syndrome. The research targets dysregulated microRNA expression, specifically the mir-183/96/182 cluster identified as significantly downregulated in Angelman syndrome model mice. The study tests whether...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- The National Institute of Child Health and Human Development awarded $644,771 to the Research Institute at Nationwide Children's Hospital on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Program R01HD119141) to identify novel genes controlling craniofacial development using forward genetics in the mouse. The research uses N-ethyl-N-nitrosourea (ENU) mutagenesis to generate heritable single base-pair substitutions in the mouse genome and...
- The National Institute of Child Health and Human Development awarded Duke University $581,258 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transposable elements as mechano-response enhancer elements regulating human embryonic stem cell fate. The research examines how mechanical forces regulate transposable element sequences that control gene expression and pluripotent stem cell differentiation. The project tests three...
- The National Institute of Child Health and Human Development awarded The General Hospital Corporation (Massachusetts General Hospital) $538,173 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, assistance type: Project Grant) to investigate the molecular mechanisms controlling developmental timing through NADH redox metabolism. The project uses a segmentation clock—a molecular oscillator whose period correlates with embryonic development...
- Federal Project Grant Award Summary The Ohio State University received a $2,130,924 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This award supports fundamental research into developmental regulation of oscillatory gene expression, specifically investigating the segmentation clock mechanism that controls somitogenesis—the...