Project Grant R21HD120965
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services, awarded the University of California, San Diego $657,971 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate dopamine's role in neuroimmunoendocrine mechanisms underlying spontaneous preterm birth. The research integrates pathological, physiological, and psychological mechanisms preceding spontaneous preterm birth to...
- The National Institute of Child Health and Human Development awarded University of California, San Diego $663,493 on June 4, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to conduct research on the immune cell-placenta-serotonin axis in peripartum depression and selective serotonin reuptake inhibitor (SSRI) therapy. The research addresses peripartum depression (including antenatal-onset depression), which affects approximately one in four...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $440,000 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize brainstem noradrenergic circuits controlling reproductive function. The research investigates how chronic psychosocial stress impairs reproductive capacity through inhibition of hypothalamic kisspeptin neuron function, which leads to reduced luteinizing...
- Federal Grant Award Summary The University of California, San Diego received a $452,000 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion by July 31, 2027. This research project aims to identify a cellular immune signature unique to clinically-significant villitis of unknown etiology (VUE), a chronic inflammatory placental lesion...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $650,472 on September 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate how adrenergic signaling from brainstem norepinephrine neurons regulates reproductive neuroendocrine circuits in response to chronic psychosocial stress. The research addresses how stress impairs kisspeptin neuron function and downstream luteinizing...
- The National Institute of Child Health and Human Development awarded Cincinnati Children's Hospital Medical Center $140,072 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how white adipose tissue inflammation in pregnancy affects labor timing and preterm birth risk. The research uses a mouse pregnancy model to define sources of pro-inflammatory cytokine production throughout pregnancy, with specific focus on how white...
- The National Institute of Allergy and Infectious Diseases awarded $805,497 to The Regents of the University of California, San Francisco on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fibroblast-immune cell interactions in the epigenetic control of parturition timing. The research seeks to identify cellular and molecular pathways controlling labor onset in mice, with emphasis on how uterine fibroblast epigenomes evolve during gestation...
- The National Institute of Child Health and Human Development awarded The University of Texas Southwestern Medical Center $248,999 on June 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support multiscale experimental and computational characterization of pregnancy-induced remodeling of pelvic floor skeletal muscle. The award funds Phase 1 (K99) experimental research examining how sex hormones and mechanical stretch affect pelvic floor muscle...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $153,560 on December 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate gene regulatory mechanisms driving totipotency induction in human stem cells. The research examines how RNA splicing dysfunction alters early human development through integrative transcriptomic, epigenomic, and proteomic profiling. The work focuses on...
The National Institute of Child Health and Human Development awarded University of California, San Diego $440,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate uterine neuronal innervation dynamics and immune function during the peripartum period. The research maps sympathetic, parasympathetic, and sensory neuronal subtypes across uterine layers in mice, describing their spatial and temporal distribution with proteomic resolution and defining neuroimmune niches—interaction sites between uterine-innervating axons and resident immune cells. The study tests the functional role of these neuronal subtypes in reshaping uterine immune phenotypes and function during pregnancy, labor, and the postpartum transition, addressing complications that affect 30–40 percent of pregnant women, including unexplained idiopathic cases such as spontaneous preterm birth affecting one to two in 100 pregnancies. Work is performed at UC San Diego's La Jolla campus with a period of performance from September 1, 2026, through August 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/31/26 | ||
| Not listed | $440.0k | 8/28/26 |