Project Grant R37AI198470
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, San Francisco a five-year Project Grant totaling $805,497 (awarded June 1, 2026, with completion by May 31, 2031) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project investigates fibroblast-immune cell interactions in the epigenetic control of parturition timing, with the overarching goal of identifying...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $874,531 on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to model dynamic CD8+ T cell–virus interactions in post-treatment control of HIV. The project comprehensively defines mechanistic features of CD8+ T cell responses that most strongly relate to control of HIV after stopping antiretroviral therapy. Research will examine...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $201,744 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to determine key features of immunity associated with protection against pregnancy-associated malaria. The research leverages a longitudinal cohort of Ugandan pregnant women to characterize antibody responses targeting the P. falciparum VAR2CSA protein, which mediates...
- The National Institute of Allergy and Infectious Diseases awarded $201,744 to The Regents of the University of California, San Francisco on April 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research into transcriptional mechanisms that drive dysregulated type 17 mucosal inflammation via innate lymphoid cells. The project investigates how group 3 innate lymphoid cells (ILC3s) trigger and sustain aberrant type 17 immune responses in chronic...
- The National Institute of Allergy and Infectious Diseases awarded $138,903 to the University of California, San Diego on January 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify and characterize novel transcriptional regulators associated with antiphage immune systems in clinically important bacterial pathogens. The funded research focuses on gene regulation within bacterial defense islands. The recipient will define the upstream signals and...
- The National Institute of Child Health and Human Development awarded University of California, San Diego $440,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate uterine neuronal innervation dynamics and immune function during the peripartum period. The research maps sympathetic, parasympathetic, and sensory neuronal subtypes across uterine layers in mice, describing their spatial and temporal distribution with proteomic...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $174,824 on April 6, 2026, to develop a humanized IL33 mouse model for allergic disease research under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will engineer and characterize a mouse strain carrying the human IL33 gene sequence, including approximately 28 kilobases upstream of exon 1 through approximately 21 kilobases downstream...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $666,065 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular basis for immunogenic B cell responses to virus-like antigen display. The research leverages a modular platform of liposomes decorated with model antigens to independently control epitope affinity and density. The work aims to identify proximal...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $816,421 on April 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study the interplay of heterosexual male-female partner microbiomes, Chlamydia trachomatis infection, and transmission dynamics. The research addresses a gap in knowledge about urethral C. trachomatis infections in men who have sex only with women and transmission to...
- The National Institute of Allergy and Infectious Diseases awarded the University of South Florida $791,245 on May 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate placental antiviral defense mechanisms. The funded research, organized around two specific aims, will elucidate how human trophoblasts produce type III interferons and defend against viral threats at the maternal-fetal interface. Aim 1 will define the mechanisms by which...
The National Institute of Allergy and Infectious Diseases awarded $805,497 to The Regents of the University of California, San Francisco on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fibroblast-immune cell interactions in the epigenetic control of parturition timing. The research seeks to identify cellular and molecular pathways controlling labor onset in mice, with emphasis on how uterine fibroblast epigenomes evolve during gestation and how locus-specific erosion of the repressive histone mark H3K27ME3 regulates intra- and intercellular signaling. The project addresses both natural parturition and inflammation-induced preterm birth pathways, including those activated through innate type 2 immunity, to inform understanding of labor mechanisms in humans and advance development of predictive diagnostics and therapies for preterm birth. Work is performed in San Francisco, California, with a period of performance from June 1, 2026, through May 31, 2031. This is a Project Grant, an assistance type supporting hypothesis-driven biomedical research at academic institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/3/26 | ||
| Not listed | $805.5k | 6/1/26 |