This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $630,107 to Childrens Hospital Medical Center in Cincinnati, Ohio to study the role of human leukocyte antigen-C (HLA-C) in chronic chorioamnionitis.
The research aims to determine how cytotoxic CD8 T cells contribute to trophoblast death during chronic chorioamnionitis, a condition involving inflammation of the placental membranes. The project will utilize advanced techniques like high-dimensional flow cytometry and single-cell RNA sequencing to identify the cellular pathways and communication networks that regulate CD8 T cell cytotoxicity and trophoblast killing. The findings are expected to provide transformative insights into the etiology of chronic chorioamnionitis. The award period runs from January 1, 2025 to November 30, 2029.
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