Project Grant R21HD118230
- The National Institute of Child Health and Human Development awarded $568,925 to the Board of Regents of the University of Nebraska on September 1, 2026, to conduct pharmacokinetic, pharmacodynamic, safety, and efficacy studies of targeted nanoparticle drug delivery to the placenta under CFDA 93.865 (Child Health and Human Development Extramural Research). The research addresses placental dysfunction, the underlying cause of preeclampsia, intrauterine growth restriction, and stillbirth, which...
- The National Institute of Child Health and Human Development, an office of the Department of Health and Human Services, awarded $600,016 to the University of California, San Diego on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate extracellular vesicles as mediators of kidney damage in preeclampsia. The research employs a three-dimensional microfluidic human proximal tubule kidney-on-a-chip model to study how placental and serum...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health National Institute of Child Health and Human Development provides $769,916 to Emergent Biotechnologies LLC for research into a novel therapy for preeclampsia. The funding supports Phase 1 of developing and characterizing a handle region peptide as an innovative treatment for preeclampsia under the Child Health and Human Development Extramural Research program (CFDA 93.865). Phase 1 work will...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- The National Institute of Child Health and Human Development awarded Duke University $694,448 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research analyzing local and global responses in the placenta syncytiotrophoblast. The research investigates the multinucleated syncytiotrophoblast, a giant single cell that separates maternal and fetal vasculature during pregnancy and performs critical functions including nutrient...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded $429,000 in Project Grant funding to the University of Colorado-Denver for research conducted under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award was obligated on August 6, 2025, with a project completion date of July 31, 2027. This R21 mechanism grant supports research utilizing induced pluripotent stem cell (iPSC)...
- The National Institute of Child Health and Human Development (NICHD) awarded a $429,000 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to develop a new imaging tool to assess placental hemodynamics during pregnancy. The study aims to determine if Subharmonic Aided Pressure Estimation (SHAPE) using contrast-enhanced ultrasound can provide a safe, non-invasive, and real-time method...
- The National Institute of Child Health and Human Development awarded $453,698 to Brigham & Women's Hospital Inc. on August 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and validate chemogenetic animal models of preeclampsia for identifying novel pharmacological targets. The research exploits a transgenic mouse line expressing a recombinant yeast D-amino acid oxidase that generates hydrogen peroxide in vascular endothelium when...
- The National Institute of Child Health and Human Development awarded The Trustees of Princeton University $315,664 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how amniotic fluid pressure and composition regulate branching morphogenesis across embryonic organs. The research tests the hypothesis that amniotic fluid couples the rate of branching morphogenesis in organs throughout the embryo, with particular focus on...
The National Institute of Child Health and Human Development awarded Rowan University $408,380 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop hypoxia-responsive lipid nanoparticles for delivery of placental growth factor messenger RNA and soluble FMS-like tyrosine kinase-1 small interfering RNA to treat preeclampsia. The research addresses preeclampsia through targeted drug delivery to diseased placental tissue. The project builds on prior work identifying an lipid nanoparticle platform for placental delivery of placental growth factor messenger RNA. The funded work expands this technology by engineering hypoxia-responsive lipids to increase intracellular nucleic acid delivery specifically to hypoxic tissues, with the hypothesis that this approach will restore the balance of angiogenic and anti-angiogenic factors and promote placental angiogenesis as a therapeutic intervention for preeclampsia. Performance runs from September 1, 2026, through August 31, 2028, at Rowan University in Glassboro, New Jersey. The award is classified as a Project Grant, a standard assistance type for investigator-initiated biomedical research under NICHD extramural programs.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.4k | 8/26/26 |