This federal Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research), supports research to evaluate the mechanisms of cell-free fetal DNA signaling in the promotion of labor. The $139,446 award, with a performance period from August 2024 to January 2025, will enable the grantee, Mayo Clinic, to pursue two key research objectives: 1) Evaluating...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 Child Health and Human Development Extramural Research provides $429,000.00 to the University of Colorado-Denver for a 2-year project to develop optogenetic and chemogenetic models to regulate uterine vascular function and prevent fetal growth restriction (FGR). The key products and services to be delivered through this award include: Establishing mouse models expressing...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $442,550 to quantify altered placental microstructure and correlate microstructural changes with preeclampsia. The awardee, The Administrators of the Tulane Educational Fund (Tulane University), will develop quantitative ultrasound (QUS) methods to characterize the human placenta ex vivo and...
The federal Project Grant award of $248,120 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to determine the impact of the small intestinal microbiota of undernourished mothers with environmental enteric dysfunction (EED) on vascular remodeling at the maternal-fetal interface. The goal is to advance understanding of how maternal undernutrition and associated...
This federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, supports research to investigate the role of TLR7/8-activating microRNAs in driving fetal inflammatory response syndrome and associated developmental consequences. The total award of $132,779 will enable the Principal Investigator at Yale University to determine if exosomes...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 - Child Health and Human Development Extramural Research, will fund a computational modeling study to investigate uteroplacental hemodynamics and its implications for placental development and fetal health. The $766,982 award to Carnegie Mellon University will develop and validate a novel computational framework to simulate uteroplacental...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $125,814 to The Regents of the University of California, San Francisco (UCSF) to quantify germ cell lineage dynamics during mammalian oogenesis. The goal is to characterize germ cell selection and determine the functional importance of early germ cell heterogeneity for shaping...
The University of Vermont & State Agricultural College, a public land-grant research university, received a Project Grant award of $783,611.06 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, which runs from September 5, 2024 to August 31, 2027, supports research to examine how maternal inflammation and viral infection during pregnancy can...
This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) will provide $452,000 over 2 years (8/1/2025 - 7/31/2027) to researchers at the University of California, San Diego to identify cellular signatures that distinguish clinically-significant villitis of unknown etiology (VUE) associated with fetal growth restriction (FGR).
The goal is to apply high-throughput mass cytometry to placental tissues and immune cell isolates to unravel the pathophysiology of VUE and identify cellular profiles that can distinguish VUE lesions causative of FGR from more benign forms. This research aims to lay the foundation for developing diagnostic biomarkers for late-onset FGR, which is often linked to stillbirth. By advancing the understanding of VUE, this project has the potential to improve identification and management of this placental condition associated with adverse pregnancy outcomes.