The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $390,000 to Thomas Jefferson University (Sidney Kimmel Medical College) to evaluate the use of contrast-enhanced ultrasound (CEUS) and subharmonic-aided pressure estimation (SHAPE) techniques for assessing uterine fibroids before and after uterine artery embolization (UAE) procedures. The goals...
This $429,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to determine if blood perfusion and microvascular pressure around the internal os of the uterine cervix can distinguish patients with a history of cervical insufficiency (CI) from normal controls in a non-pregnant state. The researchers at Thomas Jefferson University will use contrast-enhanced...
This Project Grant award, identified as R21HD115115, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $383,491 award supports the development and validation of a novel computational framework to simulate uteroplacental hemodynamics and investigate the potential for applying these models to the early detection of pregnancy complications. The research, conducted by...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $442,550 to quantify altered placental microstructure and correlate microstructural changes with preeclampsia. The awardee, The Administrators of the Tulane Educational Fund (Tulane University), will develop quantitative ultrasound (QUS) methods to characterize the human placenta ex vivo and...
The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
This Project Grant award, valued at $293,756, was provided by the National Institutes of Health (NIH) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Institute for Systems Biology (ISB). The funding will support research to enhance understanding of placental dysfunction in common obstetric disorders like preeclampsia, preterm birth, and fetal growth restriction. The research aims to identify molecular mechanisms and network-level patterns...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research to develop a targeted, placenta-tropic lipid nanoparticle (LNP) platform for the delivery of mRNA therapeutics to treat pre-eclampsia, a serious pregnancy complication. The $349,375 award will fund the evaluation of a large library of novel ionizable LNPs for placental tropism,...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is focused on developing epigenomic liquid biopsy methods for early detection and prediction of preterm birth, preeclampsia, and intrauterine growth restriction. The total grant award of $717,871 to the Magee-Womens Research Institute and Foundation aims to create non-invasive screening tools to...
This Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to develop non-invasive magnetic resonance imaging (MRI) techniques to predict fetal growth early in pregnancy. The $295,212 award, with a project period from September 1, 2024 to August 31, 2026, will be used by the University of South Australia to conduct a preclinical study in...
The National Institute of Child Health and Human Development (NICHD) awarded a $429,000 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to develop a new imaging tool to assess placental hemodynamics during pregnancy. The study aims to determine if Subharmonic Aided Pressure Estimation (SHAPE) using contrast-enhanced ultrasound can provide a safe, non-invasive, and real-time method to evaluate human uteroplacental vascularization in early pregnancy. The research will investigate if pressure gradient indices and the standard deviation of pressure estimates in the placental bed can correlate with the degree of uteroplacental vascularization and gestational age in normal pregnancies. The award period runs from September 16, 2024, to August 31, 2026.